Spevak S E, Shekhter A B, Hilse H, Oehme P, Solov'eva A I
Biull Eksp Biol Med. 1989 Jun;107(6):739-43.
The paper demonstrates that in spontaneously hypertensive rats (SHR) as compared with normotensive controls exudative processes at the sites of lesions are much more prominent. Such exudative processes include edema, fibrinous exudation as well as permeability of capillaries and venular walls for leukocytes. These effects prolong the phase of its inflammation and retard the regeneration phase in wound healing. Morphine and SP1-11 stimulate in a similar fashion repair during wound healing in the both rat strains. Their effect is similar to the effect of opioid peptides. SP1-4 does not affect vessel reactivity and wound healing in SHR, which is related to disturbed expression of receptors to SP fragments. Synergism in the effect of two functional antagonists i.e. opioids and SP on wound healing confirms our hypothesis about the role of pain as an inducer of a variety of mechanisms underlying repair regeneration.
该论文表明，与正常血压对照组相比，自发性高血压大鼠（SHR）损伤部位的渗出过程更为显著。此类渗出过程包括水肿、纤维素渗出以及毛细血管和小静脉壁对白细胞的通透性。这些作用延长了其炎症阶段，并延缓了伤口愈合中的再生阶段。吗啡和SP1-11以类似方式刺激两种大鼠品系伤口愈合过程中的修复。它们的作用类似于阿片肽的作用。SP1-4不影响SHR的血管反应性和伤口愈合，这与SP片段受体表达紊乱有关。两种功能性拮抗剂即阿片类药物和SP对伤口愈合的协同作用证实了我们关于疼痛作为修复再生多种机制诱导因素作用的假设。
