Kramer G C, Walsh J C, Perron P R, Gunther R A, Holcroft J W
Department of Human Physiology, University of California, Davis 95616.
Braz J Med Biol Res. 1989;22(2):279-82.
In the present study, we compare resuscitation of bled sheep with hypertonic saline/dextran or hypertonic saline/hetastarch. Unanesthetized sheep were subjected to 2 h of hemorrhagic hypotension and then resuscitated with 200 ml of 7.5% NaCl solution made up to include either 6% dextran 70 (Macrodex) or 6% hetastarch (Hespan). Both solutions provided an immediate and sustained improvement in arterial pressure and cardiac output. The hypertonic saline/dextran provided a slightly better overall response as mean arterial pressure, cardiac output and central venous pressure were higher in the dextran group at all times post resuscitation. However, only the differences in arterial pressure and initial plasma volume expansion were statistically significant. The somewhat better response to hypertonic saline/dextran may be explained by the higher oncotic pressures generated by dextran compared to equal concentrations of hetastarch.
在本研究中，我们比较了用高渗盐水/右旋糖酐或高渗盐水/羟乙基淀粉对失血绵羊进行复苏的效果。未麻醉的绵羊经历2小时的失血性低血压，然后用200毫升由7.5%氯化钠溶液组成的溶液进行复苏，该溶液中加入了6%的右旋糖酐70（Macrodex）或6%的羟乙基淀粉（Hespan）。两种溶液均能使动脉压和心输出量立即且持续改善。高渗盐水/右旋糖酐的总体反应稍好一些，因为复苏后右旋糖酐组的平均动脉压、心输出量和中心静脉压在所有时间点都更高。然而，只有动脉压和初始血浆容量扩充的差异具有统计学意义。与同等浓度的羟乙基淀粉相比，右旋糖酐产生的较高胶体渗透压可能解释了对高渗盐水/右旋糖酐的反应稍好的原因。
