Azab M, Droz J P, Theodore C, Wolff J P, Amiel J L
Department of Medical Oncology, Institut Gustave-Roussy, Villejuif, France.
Cancer. 1989 Nov 1;64(9):1829-32. doi: 10.1002/1097-0142(19891101)64:9<1829::aid-cncr2820640912>3.0.co;2-g.
Eight patients with high-risk gestational trophoblastic tumors (GTT) resistant to multiagent chemotherapy were treated with the combination of cisplatin, vinblastine, and bleomycin (PVB). All patients had a metastatic disease including three patients with two metastatic sites and two patients with brain metastases. Four patients achieved complete remission (CR) with the PVB regimen (50%). Three additional patients had partial remission (PR) of whom two were converted into CR by surgery of resistant residual lesions. One patient relapsed and the remaining five patients in CR were cured (62%). A multimodal approach was necessary in most patients as five of them had hysterectomy and two patients had a whole-brain irradiation. Toxicity was mild with no treatment related deaths.
8例对多药化疗耐药的高危妊娠滋养细胞肿瘤（GTT）患者接受了顺铂、长春碱和博来霉素（PVB）联合治疗。所有患者均有转移性疾病，其中3例有两个转移部位，2例有脑转移。4例患者通过PVB方案实现完全缓解（CR）（50%）。另外3例患者部分缓解（PR），其中2例通过对耐药残留病灶进行手术转为CR。1例患者复发，其余5例CR患者治愈（62%）。大多数患者需要采用多模式方法，其中5例接受了子宫切除术，2例接受了全脑照射。毒性较轻，无治疗相关死亡。
