容积敏感型和钙激活氯通道的功能。
Functions of volume-sensitive and calcium-activated chloride channels.
作者信息
Hoffmann Else Kay, Holm Niels Bjerre, Lambert Ian Henry
机构信息
Department of Biology, University of Copenhagen, 13 Universitetsparken, Copenhagen Ø, Denmark.
出版信息
IUBMB Life. 2014 Apr;66(4):257-67. doi: 10.1002/iub.1266. Epub 2014 Apr 28.
DOI:10.1002/iub.1266
PMID:24771413
Abstract
The review describes molecular and functional properties of the volume regulated anion channel and Ca(2+)-dependent Cl(-) channels belonging to the anoctamin family with emphasis on physiological importance of these channels in regulation of cell volume, cell migration, cell proliferation, and programmed cell death. Finally, we discuss the role of Cl(-) channels in various diseases.
摘要
这篇综述描述了容积调节性阴离子通道以及属于八聚体家族的钙依赖性氯通道的分子和功能特性，重点阐述了这些通道在调节细胞容积、细胞迁移、细胞增殖和程序性细胞死亡方面的生理重要性。最后，我们讨论了氯通道在各种疾病中的作用。
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