Sulis E, Floris C, Massidda C
Divisione Medicina I, Ospedale Oncologico A. Businco, Cagliari, Italy.
Cancer Chemother Pharmacol. 1989;24(6):393-4. doi: 10.1007/BF00257450.
In five patients with regional lymph nodal metastases from malignant melanoma of the lower limbs, intralymphatic infusion of interferon caused a complete remission in one patient and a partial remission in two others. The remaining two patients, in whom the massive neoplastic infiltration had obstructed the inflow of the drug in the tumoural seat, were unresponsive. Since the efficacy of interferon seems to be dose-dependent, intralymphatic infusion causes the accumulation of massive quantities of the drug in the tumoural seat, thus favouring its antiproliferative action.
在5例下肢恶性黑色素瘤伴有区域淋巴结转移的患者中，经淋巴管内输注干扰素后，1例患者完全缓解，2例部分缓解。其余2例患者因肿瘤大量浸润阻塞了药物在肿瘤部位的流入，对治疗无反应。由于干扰素的疗效似乎与剂量有关，经淋巴管内输注可使大量药物在肿瘤部位蓄积，从而有利于其抗增殖作用。
