胚胎神经组织移植对缺氧后大鼠大脑皮层RNA合成的刺激作用。
Stimulation of RNA synthesis in brain cortex of rats after hypoxia by transplantation of embryonic nervous tissue.
作者信息
Polezhaev L V, Saburina I N, Cherkasova L V, Vitvitsky V N, Timonin A V
机构信息
N. I. Vavilov Institute of General Genetics, USSR Academy of Sciences, Moscow.
出版信息
J Hirnforsch. 1989;30(4):461-4.
Our early studies (Polezhaev and Alexandrova, 1986) have shown that acute hypoxic hypoxia in rats causes mass (up to 36%) diffuse dystrophy of brain cortex neurons and that after transplantation of embryonic nervous tissue (ENT) into the brain of hypoxia-exposed rats the dystrophy and death of cortical neurons are reduced to 25% due to normalization of a part of dystrophic neurons. In the present work we studied changes in the RNA synthesis in neurons and in the total brain cortex of rats after hypoxia and subsequent transplantation of ENT into their brain by the autoradiographic and biochemical methods using 14C-adenine. It has been shown that under the action of hypoxia the RNA synthesis in neurons and in the total brain cortex of rats is reduced and after transplantation of ENT into the brain of these rats the RNA synthesis is stimulated and normalized both in neurons and in the total brain cortex.
我们早期的研究（波列扎耶夫和亚历山德罗娃，1986年）表明，大鼠急性低氧性缺氧会导致大脑皮层神经元大量（高达36%）弥漫性营养不良，并且在将胚胎神经组织（ENT）移植到缺氧大鼠大脑后，由于部分营养不良神经元的正常化，皮层神经元的营养不良和死亡减少到25%。在本研究中，我们使用14C-腺嘌呤通过放射自显影和生化方法研究了大鼠缺氧以及随后将ENT移植到其大脑后神经元和整个大脑皮层中RNA合成的变化。结果表明，在缺氧作用下，大鼠神经元和整个大脑皮层中的RNA合成减少，而将ENT移植到这些大鼠大脑后，神经元和整个大脑皮层中的RNA合成均受到刺激并恢复正常。
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