Chatzikyriakidou Anthoula, Aidinidou Louiza, Giannopoulos Andreas, Papadopoulou-Legbelou Kyriaki, Kalinderi Kallirhoe, Fidani Liana
1Department of General Biology,Medical School,Aristotle University of Thessaloniki,Greece.
22nd Department of Pediatric,Pediatric Cardiology Clinic,Ahepa University Hospital,Aristotle University of Thessaloniki,Greece.
Cardiol Young. 2015 Apr;25(4):681-3. doi: 10.1017/S1047951114000626. Epub 2014 Apr 28.
Kawasaki disease is an acute, febrile syndrome in infancy, characterised by vasculitis of medium-sized arteries, and affects predominantly young children. Family-based studies on Kawasaki disease supports the contribution of genetic factors in disorder manifestation. In a recent genome-wide association study, the polymorphism rs1801274 of FCGR2A [Fc fragment of immunoglobulin G, low-affinity IIa, receptor] gene has been implicated in disease pathogenesis. The aim of the present study was to explore the association of this variant, for the first time, in a group of Kawasaki-diseased patients of Greek origin. A total of 47 Kawasaki-diseased children and 50 control subjects were enrolled in the study. Polymerase chain reaction-restriction fragment length polymorphism assay was performed in rs1801274 genotyping. No association was observed between this polymorphism genotypes' or alleles' distribution between Kawasaki-diseased patients and controls. Furthermore, no association was revealed between this polymorphism and cardiovascular complications in Kawasaki-diseased patients. In the literature, the reported data over this polymorphism association with Kawasaki disease in Caucasian patients are contradictory. In addition, the disease shows low prevalence in the Caucasian populations. Therefore, the independent genetic association studies on rs1801274 with Kawasaki disease in various Caucasian groups increase the amount of genetic data, which could be used in a future meta-analysis, increasing the statistical power of the resultant conclusions.
川崎病是一种婴幼儿期的急性发热综合征，其特征为中等大小动脉的血管炎，主要影响幼儿。基于家庭的川崎病研究支持遗传因素在疾病表现中的作用。在最近一项全基因组关联研究中，FCGR2A[免疫球蛋白G低亲和力IIa受体的Fc片段]基因的rs1801274多态性与疾病发病机制有关。本研究的目的是首次在一组希腊裔川崎病患者中探讨该变异的关联。共有47名川崎病患儿和50名对照受试者纳入研究。对rs1801274进行基因分型时采用聚合酶链反应-限制性片段长度多态性分析。在川崎病患者和对照之间未观察到该多态性基因型或等位基因分布的关联。此外，在川崎病患者中该多态性与心血管并发症之间也未显示出关联。在文献中，关于该多态性与白种人患者川崎病关联的报道数据相互矛盾。此外，该疾病在白种人群中的患病率较低。因此，在不同白种人群中对rs1801274与川崎病进行独立的基因关联研究增加了遗传数据量，这些数据可用于未来的荟萃分析，提高所得结论的统计效力。
