Li T, Nagayama N, Kawabe Y, Ohtsuka Y, Machida K, Haga T
Nihon Kyobu Shikkan Gakkai Zasshi. 1989 Apr;27(4):488-96.
Serum amylase level was examined in 129 cases (225 episodes) of chronic respiratory failure at acute exacerbation, and in 59 cases (62 episodes) of pneumonia without respiratory failure as a control. Cases accompanying diseases, such as acute pancreatitis, parotiditis, ileus, and renal dysfunction, which were expected to develop hyperamylasemia were excluded. The 225 episodes were divided according to the cause of acute exacerbation into 4 groups: pneumonia, bronchitis, right heart failure without infection, and others (e.g. hemoptysis). Hyperamylasemia (greater than 400 S-U) was observed in groups of pneumonia (15/40 = 35.5%) and of bronchitis (12/95 = 12.6%) respectively, but not in those of right heart failure without infection (0/73 = 0%) and others (0/17 = 0%). As a result, hyperamylasemia was found only under conditions of inflammation of lung parenchyma and bronchi with acute exacerbation of respiratory failure. On the other hand no hyperamylasemia was observed in 62 episodes of only pneumonia without respiratory failure. It was concluded that both respiratory tract infection and acute respiratory failure are necessary factors for development of hyperamylasemia originating from lung or bronchi.
对129例（225次发作）慢性呼吸衰竭急性加重期患者的血清淀粉酶水平进行了检测，并以59例（62次发作）无呼吸衰竭的肺炎患者作为对照。排除了伴有急性胰腺炎、腮腺炎、肠梗阻和肾功能不全等预计会出现高淀粉酶血症的疾病的病例。根据急性加重的原因，将这225次发作分为4组：肺炎、支气管炎、无感染的右心衰竭和其他（如咯血）。肺炎组（15/40 = 35.5%）和支气管炎组（12/95 = 12.6%）分别观察到高淀粉酶血症（大于400 S-U），但无感染的右心衰竭组（0/73 = 0%）和其他组（0/17 = 0%）未观察到。结果发现，仅在肺实质和支气管炎症伴呼吸衰竭急性加重的情况下出现高淀粉酶血症。另一方面，在62次仅为无呼吸衰竭的肺炎发作中未观察到高淀粉酶血症。得出的结论是，呼吸道感染和急性呼吸衰竭都是源于肺或支气管的高淀粉酶血症发生的必要因素。
