人乳头瘤病毒阳性扁桃体癌和舌根癌中HLA - A*02与预后的关系
HLA-A*02 in relation to outcome in human papillomavirus positive tonsillar and base of tongue cancer.
作者信息
Tertipis Nikolaos, Villabona Lisa, Nordfors Cecilia, Näsman Anders, Ramqvist Torbjörn, Vlastos Andrea, Masucci Giuseppe, Dalianis Tina
机构信息
Department of Oncology-Pathology, Karolinska Institutet, Cancer Center Karolinska, R8:01 Karolinska University Hospital, 171 76 Stockholm, Sweden.
出版信息
Anticancer Res. 2014 May;34(5):2369-75.
BACKGROUND/AIM: Patients with human papillomavirus (HPV)-positive tonsillar and base of tongue cancer have a better outcome than those with corresponding HPV-negative tumors (80% vs. 40% 5-year disease free survival with conventional radiotherapy). They should not all need chemoradiotherapy, but before tapering treatment, more markers are needed to predict treatment response. In the present study, human leukocyte antigen (HLA) - HLA-A*02 was analyzed with HPV as a prognostic factor for tonsillar and base of tongue cancer.
PATIENTS AND METHODS
Pre-treatment biopsies, previously tested for HPV DNA, from 425 patients diagnosed with tonsillar and base of tongue cancer between 2000-2009 at the Karolinska University Hospital were examined for HLA-A*02.
RESULTS
HLA-A02 was present in 144/305 (47.2%) of the HPV-positive and 63/120 (52.8%) of the HPV-negative tumours. Among 383 patients treated with curative intent, absence of HLA-A02 was correlated with increased disease-free survival in the HPV-positive (p=0.016), but not in the HPV-negative group.
CONCLUSION
Absence of HLA-A*02 correlated with better disease-free survival for patients with HPV-positive tonsillar and base of tongue cancer.
背景/目的：人乳头瘤病毒（HPV）阳性的扁桃体癌和舌根癌患者的预后优于相应的HPV阴性肿瘤患者（传统放疗后5年无病生存率分别为80%和40%）。他们并非都需要放化疗，但在缩减治疗前，需要更多标志物来预测治疗反应。在本研究中，分析了人类白细胞抗原（HLA）-HLA-A*02与HPV作为扁桃体癌和舌根癌的预后因素。
患者与方法
对卡罗林斯卡大学医院2000年至2009年间诊断为扁桃体癌和舌根癌的425例患者的预处理活检组织进行HLA-A*02检测，这些活检组织之前已检测过HPV DNA。
结果
HLA-A02在144/305例（47.2%）HPV阳性肿瘤和63/120例（52.8%）HPV阴性肿瘤中存在。在383例接受根治性治疗的患者中，HLA-A02缺失与HPV阳性患者无病生存率增加相关（p=0.016），但在HPV阴性组中无此相关性。
结论
HLA-A*02缺失与HPV阳性的扁桃体癌和舌根癌患者更好的无病生存率相关。
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