Jeong Jae-Uk, Chung Woong-Ki, Nam Taek-Keun, Song Ju-Young, Yoon Mee Sun, Kim Young-Chul, Kim Kyu-Sik, Oh In-Jae, Ban Hee-Jung, Kwon Seong Young, Bom Hee-Seung, Ahn Sung-Ja
Department of Radiation Oncology, Chonnam National University Hwasun Hospital, Chonnam National University Medical School, 322 Seoyong-ro, Hwasun-eup, Hwasun-gun, Jeollanam-do 519-763, South Korea.
Anticancer Res. 2014 May;34(5):2517-23.
We evaluated the relationship of early metabolic responses on (18)F-fluorodeoxyglucose-positron-emission tomography/computed tomography (PET/CT) performed within one month after concurrent chemoradiotherapy (CCRT) with local tumor control and survival in patients with advanced stage III non-small cell lung cancer (NSCLC).
One hundred and nineteen patients with unresectable stage III NSCLC who completed definitive CCRT were included. PET/CT was performed 2-4 weeks after completion of radiotherapy.
The maximum standardized uptake value (SUVmax) reduction ratio of the primary lesion (primary SRR, 80%, p<0.001), gross tumor volume (150 cm(3), p=0.036), and pre-radiotherapy ratio of SUVmax of the metastatic lymph node to that of the primary lesion (60%, p=0.05) were significantly associated with OS in multivariate analysis. The primary SRR was the only statistically significant parameter for local control.
Early metabolic response of the primary lesion after CCRT correlated with local control and overall survival in patients with unresectable stage III NSCLC.
我们评估了同步放化疗（CCRT）后1个月内进行的（18）F-氟脱氧葡萄糖正电子发射断层扫描/计算机断层扫描（PET/CT）早期代谢反应与局部肿瘤控制及晚期III期非小细胞肺癌（NSCLC）患者生存率之间的关系。
纳入119例完成确定性CCRT的不可切除III期NSCLC患者。放疗结束后2-4周进行PET/CT检查。
多因素分析显示，原发灶最大标准化摄取值（SUVmax）降低率（原发灶SRR，80%，p<0.001）、肿瘤总体积（150 cm³，p=0.036）以及放疗前转移淋巴结SUVmax与原发灶SUVmax的比值（60%，p=0.05）与总生存期显著相关。原发灶SRR是局部控制的唯一具有统计学意义的参数。
CCRT后原发灶的早期代谢反应与不可切除III期NSCLC患者的局部控制和总生存期相关。
