Jodłowska Elżbieta, Czepczyński Rafał, Czarnywojtek Agata, Rewers Amanda, Jarząbek Grażyna, Kędzia Witold, Ruchała Marek
Department of Endocrinology, Poznan University of Medical Sciences, Poznan, Poland.
Department of Gynecology, Poznan University of Medical Sciences, Poznan, Poland.
Contemp Oncol (Pozn). 2016;20(3):205-9. doi: 10.5114/wo.2016.61560. Epub 2016 Aug 4.
Similarly to the applications described in the first part of this publication, positron emission tomography with computed tomography (PET/CT) is also gaining importance in monitoring a tumour's response to therapy and diagnosing breast cancer recurrences. This is additionally caused by the fact that many new techniques (dual-time point imaging, positron emission tomography with magnetic resonance PET/MR, PET/CT mammography) and radiotracers (16α-18F-fluoro-17β-estradiol, 18F-fluorothymidine) are under investigation. The highest sensitivity and specificity when monitoring response to treatment is achieved when the PET/CT scan is made after one or two chemotherapy courses. Response to anti-hormonal treatment can also be monitored, also when new radiotracers, such as FES, are used. When monitoring breast cancer recurrences during follow-up, PET/CT has higher sensitivity than conventional imaging modalities, making it possible to monitor the whole body simultaneously. New techniques and radiotracers enhance the sensitivity and specificity of PET and this is why, despite relatively high costs, it might become more widespread in monitoring response to treatment and breast cancer recurrences.
与本出版物第一部分所述的应用类似，正电子发射断层扫描与计算机断层扫描（PET/CT）在监测肿瘤对治疗的反应和诊断乳腺癌复发方面也越来越重要。这还归因于许多新技术（双时相成像、正电子发射断层扫描与磁共振PET/MR、PET/CT乳腺摄影）和放射性示踪剂（16α-18F-氟-17β-雌二醇、18F-氟胸苷）正在研究中。当在一两个化疗疗程后进行PET/CT扫描时，监测治疗反应可达到最高的灵敏度和特异性。当使用新的放射性示踪剂（如FES）时，也可以监测对抗激素治疗的反应。在随访期间监测乳腺癌复发时，PET/CT比传统成像方式具有更高的灵敏度，从而能够同时对全身进行监测。新技术和放射性示踪剂提高了PET的灵敏度和特异性，这就是为什么尽管成本相对较高，但它在监测治疗反应和乳腺癌复发方面可能会更广泛应用的原因。
