Rigopoulos A, Ramboiu S, Georgescu I
Department of Urology, Saint Andrew General Hospital, Patras, Greece.
Department of Surgery, University of Medicine and Pharmacy of Craiova.
Curr Health Sci J. 2011 Apr;37(2):75-8. Epub 2011 Jun 19.
The treatment of perforated ulcer disease continues to evolve because of recent advances in pharmacology, bacteriology, and operative techniques. Despite antisecretory medication and Helicobacter pylori eradication, it is still the most common indication for emergency gastric surgery associated with high morbidity and mortality. A clinical study was carried out on patients with perforated gastric or duodenal ulcer, admitted in the 1st Surgery Department between 2002 and 2008. During the 7 years of study there were admitted 256 patients with perforated ulcer - 212 cases of duodenal and 44 cases of gastric perforated ulcer. The main surgical treatment option was simple closure with Graham patch, followed by ulcer excision and vagotomy with pyloroplasty. The second major objective was the topical treatment of peritonitis and consisted in the lavage of the peritoneal cavity and drainage. Distal gastric resection has now very limited indications. We recorded no complications postoperatively. In the modern treatment of ulcer, surgery is reserved for the acute (perforation and bleeding) and chronic complications (stenosis / penetration) and exceptionally or the patients with a prolonged history of uncomplicated ulcers with lack of response to conservative therapy.
由于药理学、细菌学和手术技术方面的最新进展,穿孔性溃疡疾病的治疗方法不断演变。尽管有抗分泌药物和根除幽门螺杆菌的措施,但它仍然是急诊胃手术最常见的适应症,且伴有高发病率和死亡率。对2002年至2008年期间在第一外科住院的胃或十二指肠穿孔患者进行了一项临床研究。在7年的研究期间,共收治了256例穿孔性溃疡患者,其中十二指肠穿孔212例,胃穿孔44例。主要的手术治疗选择是用格雷厄姆补片进行简单缝合,其次是溃疡切除术和迷走神经切断术加幽门成形术。第二个主要目标是腹膜炎的局部治疗,包括腹腔灌洗和引流。远端胃切除术目前的适应症非常有限。我们记录到术后无并发症。在现代溃疡治疗中,手术仅用于急性(穿孔和出血)和慢性并发症(狭窄/穿透),以及极少数有长期无并发症溃疡病史但对保守治疗无反应的患者。