通过原子力显微镜（AFM）基力谱法探索黄原胶支架的复杂力学性能。
Exploring the complex mechanical properties of xanthan scaffolds by AFM-based force spectroscopy.
机构信息
Institute of Photo-biophysics, School of Physics and Electronics, Henan University, Kaifeng, 475004 Henan, PR China.
Interdisciplinary Nanoscience Center (iNANO), Aarhus University, DK-8000 Aarhus, Denmark.
出版信息
Beilstein J Nanotechnol. 2014 Mar 27;5:365-373. doi: 10.3762/bjnano.5.42. eCollection 2014.
The polysaccharide xanthan has been extensively studied owing to its potential application in tissue engineering. In this paper, xanthan scaffold structures were investigated by atomic force microscope (AFM) in liquid, and the mechanical properties of the complex xanthan structures were investigated by using AFM-based force spectroscopy (FS). In this work, three types of structures in the xanthan scaffold were identified based on three types of FS stretching events. The fact that the complex force responses are the combinations of different types of stretching events suggests complicated intermolecular interactions among xanthan fibrils. The results provide crucial information to understand the structures and mechanical properties of the xanthan scaffold.
由于黄原胶在组织工程中的潜在应用，人们对其进行了广泛的研究。本文利用原子力显微镜（AFM）在液相中对黄原胶支架结构进行了研究，并利用基于原子力显微镜的力谱学（FS）研究了复杂的黄原胶结构的力学性能。在这项工作中，根据三种 FS 拉伸事件，确定了黄原胶支架中的三种结构类型。复杂的力响应是不同类型拉伸事件的组合这一事实表明黄原胶纤维之间存在复杂的分子间相互作用。研究结果为理解黄原胶支架的结构和力学性能提供了重要信息。
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