黄原胶作为多糖在组织工程中的应用：综述。

Application of xanthan gum as polysaccharide in tissue engineering: A review.

机构信息

School of Chemical Engineering, Yeungnam University, 280 Daehak-Ro, Gyeongsan 38541, South Korea; Department of Nano, Medical and Polymer Materials, Yeungnam University, 280 Daehak-Ro, Gyeongsan 38541, South Korea.

出版信息

Carbohydr Polym. 2018 Jan 15;180:128-144. doi: 10.1016/j.carbpol.2017.10.009. Epub 2017 Oct 5.

DOI:10.1016/j.carbpol.2017.10.009

PMID:29103488

Abstract

Xanthan gum is a microbial high molecular weight exo-polysaccharide produced by Xanthomonas bacteria (a Gram-negative bacteria genus that exhibits several different species) and it has widely been used as an additive in various industrial and biomedical applications such as food and food packaging, cosmetics, water-based paints, toiletries, petroleum, oil-recovery, construction and building materials, and drug delivery. Recently, it has shown great potential in issue engineering applications and a variety of modification methods have been employed to modify xanthan gum as polysaccharide for this purpose. However, xanthan gum-based biomaterials need further modification for several targeted applications due to some disadvantages (e.g., processing and mechanical performance of xanthan gum), where modified xanthan gum will be well suited for tissue engineering products. In this review, the current scenario of the use of xanthan gum for various tissue engineering applications, including its origin, structure, properties, modification, and processing for the preparation of the hydrogels and/or the scaffolds is precisely reviewed.

摘要

黄原胶是一种微生物高分子量胞外多糖，由黄单胞菌（革兰氏阴性细菌属，有多个不同种）产生，已广泛用作各种工业和生物医学应用（如食品和食品包装、化妆品、水基涂料、个人护理用品、石油、采油、建筑和建筑材料、药物输送）中的添加剂。最近，它在问题工程应用中显示出巨大的潜力，已经采用了各种改性方法来改性黄原胶作为多糖。然而，由于某些缺点（例如黄原胶的加工和机械性能），基于黄原胶的生物材料在某些靶向应用中还需要进一步改性，其中改性黄原胶将非常适合组织工程产品。在这篇综述中，详细回顾了黄原胶在各种组织工程应用中的使用情况，包括其来源、结构、性能、修饰和加工，以制备水凝胶和/或支架。