Dalton Trans. 2014 Apr 21;43(15):5831-9. doi: 10.1039/c3dt53263a.
A new live-cell permeable, fluorescent probe comprised of a simple salicylimine-based Schiff base (SA1) has been developed for Al3+ with nano-molar sensitivity in aqueous media. SA1 was synthesized through a simple structural modification of a recently reported receptor SA2 by the incorporation of the N,Ndiethylamino (DEA) group as a fine controllable unit. This modification affects the performance of SA1 remarkably in terms of its sensitivity, water compatibility and efficiency as well as its mechanistic aspect. The presence of the DEA group in SA1 led to its dual channel emission due to the TICT state and at the same time its hydrophobic nature was also responsible for controlling the strong hydration of Al3+ ions in aqueous media which ultimately led to the high sensitivity of SA1 for Al3+. The structure of SA1 was confirmed by single crystal X-ray diffraction and its binding with Al3+ was studied in detail using UVvisible, fluorescence and 1H NMR spectral studies along with mass determination. The effort of getting a single crystal of Al3+–SA1 led to single crystals of Cl−/NO3 − complexes of protonated SA1 which were fully characterized by their XRD studies.
一种新的基于席夫碱的简单水杨醛亚胺的可通透活细胞的荧光探针（SA1）已经被开发出来，用于检测水相中 Al3+，其灵敏度达到纳摩尔级别。SA1 通过对最近报道的受体 SA2 的简单结构修饰而合成，通过引入 N，N-二乙基氨基（DEA）基团作为一个精细可控单元。这种修饰显著影响了 SA1 的性能，包括其灵敏度、水兼容性和效率以及其机械方面。在 SA1 中存在 DEA 基团，由于 TICT 态，导致其具有双通道发射，同时其疏水性也负责控制 Al3+离子在水相中的强水合作用，这最终导致 SA1 对 Al3+具有高灵敏度。通过单晶 X 射线衍射证实了 SA1 的结构，并通过紫外可见光谱、荧光光谱和 1H NMR 光谱研究以及质量测定详细研究了其与 Al3+的结合。努力得到 SA1 与 Al3+的单晶，得到了质子化 SA1 的 Cl−/NO3−配合物的单晶，通过 XRD 研究对其进行了充分表征。
