Xie Y J, Chen M, Chen S J
Clin Exp Obstet Gynecol. 2014;41(2):186-9.
To assess the predictive value of the combination of ultrasound scanning, yolk sacs and CA125 levels for pregnancy outcomes in early threatened abortion.
A total 196 pregnant women at less than 12 weeks gestation were enrolled. They were assigned into: (A) normal pregnancy (n = 61); (B) early threatened abortion but with favorable outcomes after active treatment (n = 56); (C) pregnancy with spontaneous miscarriage and threatened abortions (n = 79). The yolk sacs were examined and serum CA125 levels were measured.
The visualization rate in groups A and B were significantly higher than that in group C. For the mean yolk sac diameter, there was a statistically significant difference between groups A and C (p < 0.05), B and C (p < 0.05), but no statistically significant differences were observed between A and B (p > 0.05). The mean serum CA125 levels were significantly different (p < 0.05) among three groups. The sensitivity, specificity, and Youden Index for predicting adverse outcomes using irregular shape, abnormal size, or non-visualization of the yolk sac were 81.01%, 85.71%, and 0.67, respectively.
The combination of ultrasound scanning of yolk sacs and measurement of serum CA125 levels is of great value for predicting pregnancy outcomes.
评估超声扫描、卵黄囊及CA125水平联合检测对早期先兆流产妊娠结局的预测价值。
纳入196例妊娠小于12周的孕妇。将她们分为：（A）正常妊娠组（n = 61）；（B）早期先兆流产但积极治疗后结局良好组（n = 56）；（C）自然流产合并先兆流产组（n = 79）。检查卵黄囊并检测血清CA125水平。
A组和B组的可视化率显著高于C组。对于卵黄囊平均直径，A组与C组之间（p < 0.05）、B组与C组之间（p < 0.05）存在统计学显著差异，但A组与B组之间未观察到统计学显著差异（p > 0.05）。三组间血清CA125平均水平存在显著差异（p < 0.05）。使用卵黄囊形状不规则、大小异常或不可视化来预测不良结局的敏感度、特异度和尤登指数分别为81.01%、85.71%和0.67。
卵黄囊超声扫描与血清CA125水平检测相结合对预测妊娠结局具有重要价值。
