Prediction of pregnancy outcomes with combined ultrasound scanning of yolk sacs and serum CA125 determinations in early threatened abortion.

OBJECTIVES

To assess the predictive value of the combination of ultrasound scanning, yolk sacs and CA125 levels for pregnancy outcomes in early threatened abortion.

MATERIALS AND METHODS

A total 196 pregnant women at less than 12 weeks gestation were enrolled. They were assigned into: (A) normal pregnancy (n = 61); (B) early threatened abortion but with favorable outcomes after active treatment (n = 56); (C) pregnancy with spontaneous miscarriage and threatened abortions (n = 79). The yolk sacs were examined and serum CA125 levels were measured.

RESULTS

The visualization rate in groups A and B were significantly higher than that in group C. For the mean yolk sac diameter, there was a statistically significant difference between groups A and C (p < 0.05), B and C (p < 0.05), but no statistically significant differences were observed between A and B (p > 0.05). The mean serum CA125 levels were significantly different (p < 0.05) among three groups. The sensitivity, specificity, and Youden Index for predicting adverse outcomes using irregular shape, abnormal size, or non-visualization of the yolk sac were 81.01%, 85.71%, and 0.67, respectively.

CONCLUSION

The combination of ultrasound scanning of yolk sacs and measurement of serum CA125 levels is of great value for predicting pregnancy outcomes.