Mangino F P, Ceccarello M, Di Lorenzo G, D'Ottavio G, Bogatti P, Ricci G
Clin Exp Obstet Gynecol. 2014;41(2):214-6.
Cervical pregnancy (CP) is a life-threatening condition that represents less than one percent of all ectopic pregnancies. Transvaginal sonography (TVS) is the gold standard for an accurate diagnosis. For hemodinamically stable women the available treatments involve a medical therapy, alone or in combination with interventional measures (hysteroscopy, angiographic embolization or laparoscopic ligation of uterine arteries).
The authors describe a CP unsuccessfully treated with methotrexate (MTX), but resolved with hysteroscopy.
A nulliparous woman arrived with low abdominal pain without vaginal bleeding at six weeks of amenorrhea. TVS revealed a gestational sac implanted in the isthmic cervical region, with a serum beta-hCG of 1,100 mUI/ml, that raised to 4,274 mUI/ml in a week, despite one intrasaccular-MTX injections and two systemic doses. The authors arranged for a hysteroscopic resection with no previous dilatation of the cervix. They did not adopt any safety precautions to their procedure.
It is difficult to define the exact role of hysteroscopy regarding CP. Despite some authors dispute on its complementary function to MTX, the authors believe that it could be used as a rescue method in case of MTX failure. The final aims of a proper management are to minimize the risk of haemorrhage and preserve women's fertility.
宫颈妊娠(CP)是一种危及生命的情况,占所有异位妊娠的比例不到1%。经阴道超声检查(TVS)是准确诊断的金标准。对于血流动力学稳定的女性,现有的治疗方法包括药物治疗,单独使用或与介入措施(宫腔镜检查、血管造影栓塞或腹腔镜结扎子宫动脉)联合使用。
作者描述了一例用甲氨蝶呤(MTX)治疗失败但通过宫腔镜检查治愈的宫颈妊娠。
一名未生育的女性在闭经六周时因下腹部疼痛前来就诊,无阴道出血。经阴道超声检查显示妊娠囊植入宫颈峡部区域,血清β - hCG为1100 mUI/ml,尽管进行了一次囊内注射MTX和两次全身给药,但一周内该数值升至4274 mUI/ml。作者安排在未预先扩张宫颈的情况下进行宫腔镜切除术。他们在手术过程中未采取任何安全预防措施。
很难确定宫腔镜检查在宫颈妊娠方面的确切作用。尽管一些作者对其作为MTX补充功能存在争议,但作者认为在MTX治疗失败的情况下,它可以用作一种挽救方法。恰当治疗的最终目标是将出血风险降至最低并保留女性的生育能力。