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竞争风险下长期入住养老院的预测因素:来自健康与退休研究的证据。

Predictors of long-term nursing home placement under competing risk: evidence from the Health and Retirement Study.

机构信息

School of Aging Studies, College of Behavioral and Community Sciences, University of South Florida, Tampa, Florida.

出版信息

J Am Geriatr Soc. 2014 May;62(5):913-8. doi: 10.1111/jgs.12781. Epub 2014 Apr 29.

Abstract

OBJECTIVES

To examine predictors of long-term nursing home placement (LTNHP) while controlling for mortality as a competing risk event.

DESIGN

Longitudinal.

SETTING

Health and Retirement Study, 1998-2010.

PARTICIPANTS

Nationally representative sample of community-living older adults (N = 10,385).

MEASUREMENTS

Longitudinal data were used with a maximum follow-up of 12 years. First, a traditional Cox proportional hazards model was estimated treating death as an uninformative censoring event. A joint cause-specific hazards model that accounts for the competing risk of mortality in estimating the risk of LTNHP was then estimated.

RESULTS

The effect of adjusting for competing risk of mortality is evident for nearly all predictors of LTNHP. Predictors were over- or underestimated in the traditional Cox model, and several predictors changed in the direction of the association, whereas others changed in magnitude. For example, after controlling for mortality, women aged 85 and older had more than twice the risk (hazard ratio = 7.23, 95% confidence interval = 5.18-10.10) of LTNHP than evidenced in the traditional Cox model.

CONCLUSION

Whenever possible, the competing risk of mortality should be recognized and adjusted in developing screening tools and predictive risk models for LTNHP.

摘要

目的

在控制死亡这一竞争风险事件的情况下,研究长期入住养老院(LTNHP)的预测因素。

设计

纵向研究。

地点

健康与退休研究,1998-2010 年。

参与者

居住在社区的具有代表性的老年人群体(N=10385)。

测量

使用纵向数据,最长随访时间为 12 年。首先,使用传统的 Cox 比例风险模型来估计,将死亡视为无信息删失事件。然后,使用联合特定原因风险模型来估计 LTNHP 的风险,该模型考虑了死亡率的竞争风险。

结果

对于几乎所有 LTNHP 的预测因素,调整竞争风险对死亡率的影响是明显的。在传统的 Cox 模型中,预测因素被高估或低估,而且一些预测因素的关联方向发生了变化,而其他预测因素的变化幅度也发生了变化。例如,在控制了死亡率后,85 岁及以上的女性入住养老院的风险是传统 Cox 模型中所显示的两倍多(风险比=7.23,95%置信区间=5.18-10.10)。

结论

在开发 LTNHP 的筛查工具和预测风险模型时,只要有可能,就应该认识到并调整死亡率的竞争风险。

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