[The role of cyclic adenosine monophosphate in simple forms of plasticity in the edible snail].

cAMP-dependence of synaptic depression and facilitation was investigated in functionally identified synaptic connection in the snail. It was found that 5 mM imidazole (phosphodiesterase activator) as well as 2 mM tolbutamide (inhibitor of cAMP-dependent protein kinase) do not change the rate of EPSPs depression during rhythmic (0.1 Hz) nerve stimulation, and do not affect facilitation. But treatment with both these drugs decreases EPSPs amplitude. Possibility of cAMP-dependent modulation of synaptic effectiveness is discussed.