Pivovarov A S, Drozdova E I, Kotliar B I
Nauchnye Doki Vyss Shkoly Biol Nauki. 1988(11):54-61.
The recording of transmembrane currents and intracellular potentials has been used to show on Helix lucorum identified neurons RPa4, RPa3 and LPa3, that pharmacologic effects on adenylate cyclase system do not influence the extinction of neuronal response to repeated local iontophoretic applications of acetylcholine to the soma. Neither cAMP-raising adenylate cyclase activator forskolin (2-6 x 10(-5) mol/l), nor cAMP-lowering phosphodiesterase activator imidazole (5 x 10(-3) mol/l) alter the dynamics of extinction of response to acetylcholine. A conclusion has been made that shortterm plasticity of cholinoreceptors in the investigated neurons is independent of intracellular cAMP level.
通过记录跨膜电流和细胞内电位，已在光亮大蜗牛中鉴定出的神经元RPa4、RPa3和LPa3上表明，对腺苷酸环化酶系统的药理作用不会影响神经元对向胞体反复局部离子电渗应用乙酰胆碱的反应消退。提高cAMP的腺苷酸环化酶激活剂福斯可林（2 - 6×10⁻⁵mol/L）和降低cAMP的磷酸二酯酶激活剂咪唑（5×10⁻³mol/L）均不会改变对乙酰胆碱反应消退的动力学。已得出结论，所研究神经元中胆碱能受体的短期可塑性与细胞内cAMP水平无关。
