Tamam Evsen, Turkyilmaz Ilser
1 Department of Prosthodontics, Dental School, Gazi University, Ankara, Turkey.
J Oral Implantol. 2014 Apr;40(2):153-9. doi: 10.1563/AAID-JOI-D-11-00083.
Implant failure is more likely to occur in persons with medically compromising systemic conditions, such as diabetes related to high blood glucose levels and inflammatory diseases related to pH levels lower than those in healthy people. The aim of this study was to investigate the effects of lower pH level and simulated- hyperglycemia on implant corrosion as these effects are critical to biocompatibility and osseointegration. The electrochemical corrosion properties of titanium implants were studied in four different solutions: Ringer's physiological solution at pH = 7.0 and pH = 5.5 and Ringer's physiological solution containing 15 mM dextrose at pH = 7 and pH = 5.5. Corrosion behaviors of dental implants were determined by cyclic polarization test and electrochemical impedance spectroscopy. Surface alterations were studied using a scanning electron microscope. All test electrolytes led to apparent differences in corrosion behavior of the implants. The implants under conditions of test exhibited statistically significant increases in I(corr) from 0.2372 to 1.007 μAcm(-2), corrosion rates from 1.904 to 8.085 mpy, and a decrease in polarization resistances from 304 to 74 Ω. Implants in dextrose-containing solutions were more prone to corrosion than those in Ringer's solutions alone. Increasing the acidity also yielded greater corrosion rates for the dextrose-containing solutions and the solutions without dextrose.
种植体失败更有可能发生在患有医学上会造成身体损害的全身性疾病的人群中，比如与高血糖水平相关的糖尿病以及与低于健康人pH值水平相关的炎症性疾病。本研究的目的是调查较低pH值水平和模拟高血糖对种植体腐蚀的影响，因为这些影响对生物相容性和骨整合至关重要。在四种不同溶液中研究了钛种植体的电化学腐蚀特性：pH = 7.0和pH = 5.5的林格氏生理溶液以及pH = 7和pH = 5.5的含15 mM葡萄糖的林格氏生理溶液。通过循环极化试验和电化学阻抗谱测定牙科种植体的腐蚀行为。使用扫描电子显微镜研究表面变化。所有测试电解质导致种植体的腐蚀行为出现明显差异。在测试条件下的种植体的I（corr）从0.2372显著增加到1.007 μAcm（-2），腐蚀速率从1.904增加到8.085 mpy，极化电阻从304降低到74 Ω。含葡萄糖溶液中的种植体比仅在林格氏溶液中的种植体更容易腐蚀。酸度增加也使含葡萄糖溶液和不含葡萄糖溶液产生更高的腐蚀速率。
