Greinix Hildegard T, Worel Nina, Just Ulrike, Knobler Robert
Medical University of Vienna, Department of Internal Medicine, I, Bone Marrow Transplantation, Austria.
Medical University of Vienna, Department of Blood Group, Serology and Transfusion Medicine, Austria.
Transfus Apher Sci. 2014 Jun;50(3):349-57. doi: 10.1016/j.transci.2014.04.005. Epub 2014 Apr 13.
Graft-versus-host disease (GvHD) is a serious complication of allogeneic hematopoietic cell transplantation causing significant morbidity and mortality. Corticosteroids are the established first-line treatment of GvHD. Patients not responding to corticosteroids have a dismal prognosis. Extracorporeal photopheresis (ECP) has objective activity in the treatment of both acute and chronic corticosteroid-refractory GvHD patients, has an excellent safety profile and is internationally well-established. ECP has been recommended by a significant number of renowned scientific organizations as an efficient treatment option for patients with GvHD. ECP has a proven corticosteroid-sparing effect and favourably impacts on survival and quality of life of responding patients.
移植物抗宿主病（GvHD）是异基因造血细胞移植的一种严重并发症，可导致显著的发病率和死亡率。皮质类固醇是公认的GvHD一线治疗药物。对皮质类固醇无反应的患者预后不佳。体外光化学疗法（ECP）在治疗急性和慢性皮质类固醇难治性GvHD患者方面具有客观疗效，安全性良好，且在国际上已得到广泛认可。许多著名科学组织已推荐ECP作为GvHD患者的一种有效治疗选择。ECP已被证明具有节省皮质类固醇的作用，并对有反应患者的生存和生活质量产生积极影响。
