Brown L F, Dvorak A M, Dvorak H F
Pathology Department, Beth Israel Hospital, Boston, MA 02215.
Am Rev Respir Dis. 1989 Oct;140(4):1104-7. doi: 10.1164/ajrccm/140.4.1104.
Solid tumors must induce new blood vessels if they are to grow beyond minimal size. As an initial step in this process, tumors secrete a vascular permeability factor that renders the local microvasculature hyperpermeable to fibrinogen and to other plasma proteins. Extravasated fibrinogen is rapidly clotted to crosslinked fibrin gel. Over time, this gel is invaded by macrophages, fibroblasts, and endothelial cells and undergoes "organization," such that it is replaced by vascularized granulation tissue and finally by mature connective tissue. This sequence of events is not unique to tumors but occurs in wound-healing and in a wide variety of other disease processes, including some that prominently affect the lung.
实体瘤若要生长超过最小尺寸，就必须诱导新血管生成。在此过程的初始阶段，肿瘤会分泌一种血管通透性因子，使局部微血管对纤维蛋白原和其他血浆蛋白具有高通透性。渗出的纤维蛋白原会迅速凝结成交联的纤维蛋白凝胶。随着时间的推移，这种凝胶会被巨噬细胞、成纤维细胞和内皮细胞侵入并经历“机化”，从而被血管化的肉芽组织取代，最终被成熟结缔组织取代。这一系列事件并非肿瘤所特有，而是发生在伤口愈合以及多种其他疾病过程中，包括一些对肺部有显著影响的疾病。
