Klenner T, Berger M R, Sosnovsky G, Rao N U, Wingen F, Schmähl D
German Cancer Research Center, Heidelberg, FRG.
Arch Geschwulstforsch. 1989;59(4):251-6.
The effectiveness to reduce tumor growth by 1-(2-chloroethyl)-3-(1-oxyl-2,2,6,6-tetramethylpiperidinyl)- 1-nitrosourea (SLCNU) and N,N,N,'N'- bis(1,2-ethanediyl)-N"-(1-oxyl-2,2,6,6-tetramethyl- 2-piperidinylaminocarbonyl)-phosphoric triamide (SLDU) was studied in osteosarcoma and MNU-induced mammary carcinoma in the SD-rat. Both compounds elicited neither an inhibitory effect on these tumors nor an increase in the mean/median life span as compared to the control group.
研究了1-(2-氯乙基)-3-(1-氧代-2,2,6,6-四甲基哌啶基)-1-亚硝基脲(SLCNU)和N,N,N,'N'-双(1,2-乙二基)-N"-(1-氧代-2,2,6,6-四甲基-2-哌啶基氨基羰基)-磷酸三酰胺(SLDU)对SD大鼠骨肉瘤和MNU诱导的乳腺癌的肿瘤生长抑制效果。与对照组相比，这两种化合物对这些肿瘤均未产生抑制作用，也未使平均/中位寿命增加。
