Wahl S M, McCartney-Francis N, Mergenhagen S E
Immunol Today. 1989 Aug;10(8):258-61. doi: 10.1016/0167-5699(89)90136-9.
Transforming growth factors (TGFs) are small polypeptides that were initially defined by their ability to induce transformation of non-neoplastic cells in culture. However, it has become increasingly clear that TGFs are not restricted in function to promoting cell growth. One type of transforming growth factor, TGF-beta, is a multifunctional molecule which has unique and potent effects on many target cells and tissues. In this article, Sharon Wahl, Nancy McCartney-Francis and Stephan Mergenhagen focus on the evolving role of TGF-beta in regulating inflammation, immune responses and tissue repair.
转化生长因子（TGFs）是一类小的多肽，最初是根据其在培养中诱导非肿瘤细胞转化的能力来定义的。然而，越来越清楚的是，TGFs的功能并不局限于促进细胞生长。一种转化生长因子，即TGF-β，是一种多功能分子，对许多靶细胞和组织具有独特而强大的作用。在本文中，莎伦·瓦尔、南希·麦卡特尼-弗朗西斯和斯蒂芬·默根哈根重点探讨了TGF-β在调节炎症、免疫反应和组织修复中不断演变的作用。
