Burgunder J M, Young W S
Laboratory of Cell Biology, National Institute of Mental Health, Bethesda, Maryland 20892.
J Chem Neuroanat. 1989 Sep-Oct;2(5):239-51.
Mapping and cortical projections of neurons containing neurokinin B (NKB) mRNA in the rat basal forebrain were studied using hybridization histochemistry and retrograde labeling. Neurokinin B mRNA was found in a small proportion of the neurons present in the magnocellular basal nucleus that project to the cortex. Most of these neurons projected to the frontal and parietal cortices, whereas only few projected to the occipital cortex and almost none to allocortical areas, including the olfactory bulb. NKB mRNA colocalization with galanin or substance P mRNAs, both found within neurons of the magnocellular basal nucleus, was not detected there. These results demonstrate a novel diffuse neocortical tachykinin input from the basal forebrain, in addition to the well-known cholinergic one.
利用杂交组织化学和逆行标记法，研究了大鼠基底前脑中含神经激肽B（NKB）mRNA的神经元的定位及其皮质投射。在投射到皮质的大细胞基底核中的一小部分神经元中发现了神经激肽B mRNA。这些神经元大多投射到额叶和顶叶皮质，而只有少数投射到枕叶皮质，几乎没有投射到包括嗅球在内的皮质下区域。未在大细胞基底核神经元内检测到NKB mRNA与甘丙肽或P物质mRNA的共定位，而这两种物质在大细胞基底核神经元内均有发现。这些结果表明，除了众所周知的胆碱能输入外，基底前脑还存在一种新的弥散性新皮质速激肽输入。
