对一种非凡病毒蛋白的新见解。
New insights into an X-traordinary viral protein.
作者信息
Schaller Torsten, Bauby Hélène, Hué Stéphane, Malim Michael H, Goujon Caroline
机构信息
Department of Infectious Diseases, King's College London London, UK.
Department of Infection, Division of Infection and Immunity, Centre for Medical Molecular Virology, University College London London, UK.
出版信息
Front Microbiol. 2014 Apr 8;5:126. doi: 10.3389/fmicb.2014.00126. eCollection 2014.
Vpx is a protein encoded by members of the HIV-2/SIVsmm and SIVrcm/SIVmnd-2 lineages of primate lentiviruses, and is packaged into viral particles. Vpx plays a critical role during the early steps of the viral life cycle and has been shown to counteract SAMHD1, a restriction factor in myeloid and resting T cells. However, it is becoming evident that Vpx is a multifunctional protein in that SAMHD1 antagonism is likely not its sole role. This review summarizes the current knowledge on this X-traordinary protein.
Vpx是一种由灵长类慢病毒的HIV-2/SIVsmm和SIVrcm/SIVmnd-2谱系成员编码的蛋白质，并被包装进病毒颗粒中。Vpx在病毒生命周期的早期阶段发挥关键作用，并且已被证明可对抗髓系细胞和静止T细胞中的一种限制因子SAMHD1。然而，越来越明显的是，Vpx是一种多功能蛋白质，因为对抗SAMHD1可能不是其唯一作用。本综述总结了关于这种非凡蛋白质的当前知识。
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