肿瘤护理中的药物基因组学。
Pharmacogenomics in oncology care.
作者信息
Filipski Kelly K, Mechanic Leah E, Long Rochelle, Freedman Andrew N
机构信息
Epidemiology and Genomics Research Program, Division of Cancer Control and Population Sciences, National Cancer Institute Rockville, MD, USA.
Pharmacological and Physiological Sciences Branch, Division of Pharmacology, Physiology, and Biological Chemistry, National Institute of General Medical Sciences Bethesda, MD, USA.
出版信息
Front Genet. 2014 Apr 8;5:73. doi: 10.3389/fgene.2014.00073. eCollection 2014.
Abstract
Cancer pharmacogenomics have contributed a number of important discoveries to current cancer treatment, changing the paradigm of treatment decisions. Both somatic and germline mutations are utilized to better understand the underlying biology of cancer growth and treatment response. The level of evidence required to fully translate pharmacogenomic discoveries into the clinic has relied heavily on randomized control trials. In this review, the use of observational studies, as well as, the use of adaptive trials and next generation sequencing to develop the required level of evidence for clinical implementation are discussed.
摘要
癌症药物基因组学为当前的癌症治疗带来了许多重要发现，改变了治疗决策的模式。体细胞突变和种系突变都被用于更好地理解癌症生长和治疗反应的潜在生物学机制。将药物基因组学发现全面转化为临床应用所需的证据水平在很大程度上依赖于随机对照试验。在这篇综述中，将讨论观察性研究的应用，以及使用适应性试验和下一代测序来为临床实施提供所需证据水平的情况。
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