New York Medical College, Laboratory of Molecular Reproduction and Fertility Preservation, Obstetrics and Gynecology , Valhalla, NY , USA.
Expert Opin Drug Saf. 2014 Jun;13(6):775-83. doi: 10.1517/14740338.2014.915940. Epub 2014 Apr 30.
Earlier diagnosis and novel chemotherapy strategies have resulted in a considerable improvement in cancer survival, but the quality of that survival is influenced by late effects of chemotherapy. Premature ovarian failure is a common consequence of chemotherapy in reproductive-aged women, and, as a result, fertility issues and sexual dysfunction occur frequently in women who have undergone chemotherapy.
This article reviews what is known about the effects of chemotherapy on fertility and sexuality. We also discuss risk factors for premature ovarian failure, fertility preservation options in patients willing to have a child after treatment, and sexual changes associated with estrogen withdrawal and psychological factors.
Chemotherapy-induced ovarian failure in young women is associated with poorer quality of life, decreased sexual functioning, psychosocial distress related to fertility concerns, and infertility. Fertility preservation options should be considered in women at risk of premature ovarian failure caused by chemotherapy. Sexual dysfunction associated with estrogen withdrawal and psychological stress is common in cancer survivors. Women who suffer from sexual dysfunction may benefit from brief counseling and targeted intervention.
早期诊断和新型化疗策略显著提高了癌症患者的存活率，但化疗的晚期效应会影响生存质量。化疗会导致育龄期女性发生卵巢早衰，因此，接受过化疗的女性常出现生育问题和性功能障碍。
本文综述了化疗对生育和性功能的影响。我们还讨论了卵巢早衰的风险因素、有生育需求的患者在治疗后的生育保存选择，以及与雌激素撤退和心理因素相关的性变化。
年轻女性的化疗诱导性卵巢早衰与生活质量下降、性功能下降、与生育担忧相关的心理困扰和不孕相关。有化疗引起的卵巢早衰风险的女性应考虑生育保存选择。与雌激素撤退和心理压力相关的性功能障碍在癌症幸存者中很常见。有性功能障碍的女性可能受益于简短的咨询和有针对性的干预。
