Schover Leslie R
Department of Behavioral Science-Unit 1330, The University of Texas M.D. Anderson Cancer Center, PO Box 301439, Houston, TX 77230-1439, USA.
J Clin Oncol. 2008 Feb 10;26(5):753-8. doi: 10.1200/JCO.2007.14.1655.
Premature ovarian failure is a common consequence of systemic treatment for premenopausal breast cancer. Vasomotor symptoms and sexual dysfunction occur frequently in women who have an abrupt menopause from chemotherapy or ovarian suppression. However, current fertility may be impaired even in women who are menstruating after chemotherapy, and survivors are at high risk for permanent ovarian failure at a young age. Hot flashes can be managed with venlaxafine, gabapentin, or-potentially-stress management. Providing advice on treating vaginal dryness and brief sexual counseling can often alleviate sexual dysfunction. Options for fertility preservation remain limited but are improving rapidly. Distress about interrupted childbearing has a long-term impact on the quality of life.
卵巢早衰是绝经前乳腺癌全身治疗的常见后果。血管舒缩症状和性功能障碍在因化疗或卵巢抑制而突然绝经的女性中频繁出现。然而，即使是化疗后仍有月经的女性，其当前生育能力也可能受到损害，而且幸存者在年轻时发生永久性卵巢早衰的风险很高。潮热可用文拉法辛、加巴喷丁或可能的压力管理来处理。提供治疗阴道干燥的建议和简短的性咨询通常可以缓解性功能障碍。生育力保存的选择仍然有限，但正在迅速改善。生育中断带来的困扰对生活质量有长期影响。
