Alguacil-Garcia A, O'Connor R
Department of Pathology, University of Manitoba, Winnipeg, Canada.
Histopathology. 1989 Oct;15(4):429-31. doi: 10.1111/j.1365-2559.1989.tb01597.x.
A case of extra-mammary Paget's disease with a mucin-negative small biopsy is reported. Study of a small series of vulvar Paget's disease demonstrated that areas devoid of mucin in the mm range are frequently found, creating the conditions for diagnostic problems in small biopsies. In this situation, positive immunoreactions for carcinoembryonic antigen and low molecular weight cytokeratins and a negative reaction for S-100 protein serves to differentiate Paget's disease from other pagetoid lesions.
报告了一例乳腺外佩吉特病，其小块活检组织黏液呈阴性。对一小系列外阴佩吉特病的研究表明，经常发现毫米范围内无黏液的区域，这为小块活检带来了诊断难题。在这种情况下，癌胚抗原和低分子量细胞角蛋白免疫反应呈阳性，而S-100蛋白免疫反应呈阴性，有助于将佩吉特病与其他派杰样病变区分开来。
