Odze R, Bégin L R
Department of Pathology, McGill University, Montreal, Quebec, Canada.
Int J Gynecol Pathol. 1989;8(4):374-80. doi: 10.1097/00004347-198912000-00009.
We present a case of tubular adenomatous metaplasia (nephrogenic adenoma) arising within a urethral diverticulum in a woman complaining of a vaginal mass with dyspareunia. This lesion, which uncommonly affects the urethra, may clinically manifest as a gynecologic condition and mimic a low-grade adenocarcinoma on pathologic assessment. Criteria for diagnosis and current concepts of pathogenesis are discussed. Our findings, including an immunocytochemical work-up, support the concept of a reactive metaplastic response rather than nephrogenic differentiation.
我们报告一例发生于尿道憩室的管状腺瘤样化生（肾源性腺瘤）病例，患者为一名女性，主诉有阴道肿物伴性交困难。这种病变很少累及尿道，临床上可能表现为妇科疾病，病理评估时可酷似低级别腺癌。本文讨论了诊断标准及当前的发病机制概念。我们的研究结果，包括免疫细胞化学检查结果，支持其为反应性化生反应而非肾源性分化的观点。
