Nabavizadeh Seyed Ali, Chawla Sanjeev, Baccon Jennifer, Zhang Paul J, Poptani Harish, Melhem Elias R, Vossough Arastoo
Department of Radiology, Division of Neuroradiology, Hospital of the University of Pennsylvania.
Department of Pathology, Penn State College of Medicine.
J Neuroimaging. 2014 Nov-Dec;24(6):613-616. doi: 10.1111/jon.12081. Epub 2014 Feb 19.
Extraventricular neurocytoma and ganglioneurocytoma are rare intra-axial brain neoplasms that are now recognized as distinct entities in the 2007 WHO classification of brain tumors. We describe the conventional MR imaging, perfusion MRI, proton MR spectroscopy (1H MRS), histopathology, immunohistochemistry, and chromosomal analysis in two cases of these tumors, with some features which have not been previously well described. Both tumor types demonstrated markedly elevated cerebral blood volume on perfusion MRI and had 1p19q chromosomal codeletions. Both tumor types showed an elevated Cho/Cr ratio, but extraventricular ganglioneurocytoma showed a preserved NAA/Cr ratio. These tumors should be considered in the differential diagnosis of intra-axial brain tumors.
脑室外神经细胞瘤和神经节神经细胞瘤是罕见的脑内轴内肿瘤，在2007年世界卫生组织脑肿瘤分类中被确认为不同的实体。我们描述了这两种肿瘤的常规磁共振成像、灌注磁共振成像、质子磁共振波谱（1H MRS）、组织病理学、免疫组织化学和染色体分析，其中一些特征此前尚未得到充分描述。两种肿瘤类型在灌注磁共振成像上均显示脑血容量明显升高，且有1p19q染色体缺失。两种肿瘤类型均显示胆碱/肌酸（Cho/Cr）比值升高，但脑室外神经节神经细胞瘤的N-乙酰天门冬氨酸/肌酸（NAA/Cr）比值保持正常。在脑内轴内肿瘤的鉴别诊断中应考虑这些肿瘤。
