Chan Brian T, Weiser Sheri D, Boum Yap, Haberer Jessica E, Kembabazi Annet, Hunt Peter W, Martin Jeffrey N, Mocello A Rain, Bangsberg David R, Tsai Alexander C
Division of Infectious Diseases, Massachusetts General Hospital, 55 Fruit Street GRJ 504, 02114-2696, Boston, MA, USA,
AIDS Behav. 2015 Jan;19(1):19-26. doi: 10.1007/s10461-014-0785-0.
Little is known about trends in depression at antiretroviral therapy (ART) initiation among people living with HIV (PLHIV) in low- and middle-income countries. We used data from an ongoing cohort of treatment-naïve PLHIV in rural Uganda to estimate secular trends in depression among PLHIV at ART initiation. We fitted linear regression models with depression symptom severity as the outcome variable and year of cohort entry (2005-2012) as the explanatory variable, adjusting for socio-demographic variables and assessing physical health score, body mass index (BMI), and CD4 count as potential mediators of a secular trend in depression symptom severity. There was a statistically significant negative association between year of entry and depression symptom severity, suggesting a 3.1 % relative decline in the mean depression symptom severity score at ART initiation in each year of study recruitment after the first year. This trend remained statistically significant after inclusion of baseline socio-demographic characteristics to the model and appeared to be driven by improved physical health scores, but not CD4 count or BMI.
关于低收入和中等收入国家中，开始接受抗逆转录病毒治疗（ART）的艾滋病毒感染者（PLHIV）的抑郁趋势，我们所知甚少。我们利用乌干达农村地区一组未经治疗的PLHIV队列的现有数据，来估计开始接受ART治疗的PLHIV中抑郁的长期趋势。我们拟合了线性回归模型，以抑郁症状严重程度作为结果变量，以队列入组年份（2005 - 2012年）作为解释变量，并对社会人口统计学变量进行了调整，同时评估了身体健康评分、体重指数（BMI）和CD4细胞计数，将其作为抑郁症状严重程度长期趋势的潜在中介因素。入组年份与抑郁症状严重程度之间存在统计学显著的负相关，这表明在第一年之后的每年研究招募中，开始接受ART治疗时的平均抑郁症状严重程度评分相对下降3.1%。在将基线社会人口统计学特征纳入模型后，这一趋势仍具有统计学显著性，并且似乎是由身体健康评分的改善所驱动，而非CD4细胞计数或BMI。
