Narovlianskiĭ A N, Amchenkova A M, Borukhov S I, Alimov E G, Strongin A Ia, Khesin Ia E
Mol Gen Mikrobiol Virusol. 1989 Jul(7):38-41.
The interferon-specific cellular receptors in human cells cultures differing in sensitivity to alpha-interferon have been studied. The J-41 cells resistant to alpha-interferon are practically devoid of receptors highly specific to alpha-interferon. The coefficient of equilibrium and the number of receptors analyzed after Scatchard for J-96 culture of cells are 15.6 x 10(11) M-1 and 210 +/- 90, respectively. Evidently, resistance of J-41 cells to alpha-interferon is connected with the absence of interferon receptors and, as a consequence, inability to interferon-receptor interaction.
对人细胞培养物中对α干扰素敏感性不同的干扰素特异性细胞受体进行了研究。对α干扰素具有抗性的J - 41细胞实际上缺乏对α干扰素高度特异性的受体。对J - 96细胞培养物进行Scatchard分析后得到的平衡系数和受体数量分别为15.6×10(11) M-1和210±90。显然，J - 41细胞对α干扰素的抗性与缺乏干扰素受体有关，因此无法进行干扰素 - 受体相互作用。
