正常儿童血清游离胰岛素样生长因子（IGF）-I水平

Serum Levels of Free Insulin-Like Growth Factor (IGF)-I in Normal Children.

作者信息

Nimura Atsuko, Katsumata Noriyuki, Tanaka Toshiaki

机构信息

Department of Growth and Puberty, National Research Institute for Child Health and Development, Tokyo, Japan ; Department of Growth and Puberty, National Research Institute for Child Health and Development, Tokyo, Japan.

Department of Growth and Puberty, National Research Institute for Child Health and Development, Tokyo, Japan.

出版信息

Clin Pediatr Endocrinol. 2004;13(1):71-8. doi: 10.1297/cpe.13.71. Epub 2004 Jul 7.

DOI:10.1297/cpe.13.71

PMID:24790301

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4004917/

Abstract

Serum levels of free insulin-like growth factor (IGF)-I were measured by immunoradiometric assay (IRMA) in fasting sera of 137 normal boys and 120 normal girls aged from 8 to 15 yr to study relationships between free IGF-I levels and ages, total IGF-I, IGF binding protein (IGFBP)-1, IGFBP-3, and acid-labile subunit (ALS) levels. In both sexes, serum free IGF-I levels and the ratios of free IGF-I to total IGF-I were significantly higher in the pubertal age groups than in the prepubertal age groups. Serum levels of free IGF-I showed a significant positive correlation with those of total IGF-I, IGFBP-3 and ALS, while they showed a significant negative correlation with those of IGFBP-1. These observations suggest that increase in serum free IGF-I levels during puberty is caused by a dramatic increase in total IGF-I, rather than IGFBP-3, and a decrease in IGFBP-1. Also, high free IGF-I levels may play an important role in pubertal growth spurt.

摘要

采用免疫放射分析（IRMA）法测定了137名8至15岁正常男孩和120名正常女孩空腹血清中游离胰岛素样生长因子（IGF）-I的水平，以研究游离IGF-I水平与年龄、总IGF-I、IGF结合蛋白（IGFBP）-1、IGFBP-3和酸不稳定亚基（ALS）水平之间的关系。在两个性别中，青春期年龄组的血清游离IGF-I水平以及游离IGF-I与总IGF-I的比值均显著高于青春期前年龄组。血清游离IGF-I水平与总IGF-I、IGFBP-3和ALS水平呈显著正相关，而与IGFBP-1水平呈显著负相关。这些观察结果表明，青春期血清游离IGF-I水平的升高是由总IGF-I的显著增加而非IGFBP-3的增加以及IGFBP-1的减少所致。此外，高游离IGF-I水平可能在青春期生长突增中起重要作用。