• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

正常儿童血清游离胰岛素样生长因子（IGF）-I水平

Serum Levels of Free Insulin-Like Growth Factor (IGF)-I in Normal Children.

作者信息

Nimura Atsuko, Katsumata Noriyuki, Tanaka Toshiaki

机构信息

Department of Growth and Puberty, National Research Institute for Child Health and Development, Tokyo, Japan ; Department of Growth and Puberty, National Research Institute for Child Health and Development, Tokyo, Japan.

Department of Growth and Puberty, National Research Institute for Child Health and Development, Tokyo, Japan.

出版信息

Clin Pediatr Endocrinol. 2004;13(1):71-8. doi: 10.1297/cpe.13.71. Epub 2004 Jul 7.

DOI:10.1297/cpe.13.71
PMID:24790301
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4004917/
Abstract

Serum levels of free insulin-like growth factor (IGF)-I were measured by immunoradiometric assay (IRMA) in fasting sera of 137 normal boys and 120 normal girls aged from 8 to 15 yr to study relationships between free IGF-I levels and ages, total IGF-I, IGF binding protein (IGFBP)-1, IGFBP-3, and acid-labile subunit (ALS) levels. In both sexes, serum free IGF-I levels and the ratios of free IGF-I to total IGF-I were significantly higher in the pubertal age groups than in the prepubertal age groups. Serum levels of free IGF-I showed a significant positive correlation with those of total IGF-I, IGFBP-3 and ALS, while they showed a significant negative correlation with those of IGFBP-1. These observations suggest that increase in serum free IGF-I levels during puberty is caused by a dramatic increase in total IGF-I, rather than IGFBP-3, and a decrease in IGFBP-1. Also, high free IGF-I levels may play an important role in pubertal growth spurt.

摘要

采用免疫放射分析（IRMA）法测定了137名8至15岁正常男孩和120名正常女孩空腹血清中游离胰岛素样生长因子（IGF）-I的水平，以研究游离IGF-I水平与年龄、总IGF-I、IGF结合蛋白（IGFBP）-1、IGFBP-3和酸不稳定亚基（ALS）水平之间的关系。在两个性别中，青春期年龄组的血清游离IGF-I水平以及游离IGF-I与总IGF-I的比值均显著高于青春期前年龄组。血清游离IGF-I水平与总IGF-I、IGFBP-3和ALS水平呈显著正相关，而与IGFBP-1水平呈显著负相关。这些观察结果表明，青春期血清游离IGF-I水平的升高是由总IGF-I的显著增加而非IGFBP-3的增加以及IGFBP-1的减少所致。此外，高游离IGF-I水平可能在青春期生长突增中起重要作用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4643/4004917/a6382da11e64/cpe-13-071-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4643/4004917/f982e23741d4/cpe-13-071-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4643/4004917/3af4b5bd8c99/cpe-13-071-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4643/4004917/7f59c9f42b9d/cpe-13-071-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4643/4004917/8d8037925310/cpe-13-071-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4643/4004917/a6382da11e64/cpe-13-071-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4643/4004917/f982e23741d4/cpe-13-071-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4643/4004917/3af4b5bd8c99/cpe-13-071-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4643/4004917/7f59c9f42b9d/cpe-13-071-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4643/4004917/8d8037925310/cpe-13-071-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4643/4004917/a6382da11e64/cpe-13-071-g005.jpg

相似文献

1
Serum Levels of Free Insulin-Like Growth Factor (IGF)-I in Normal Children.正常儿童血清游离胰岛素样生长因子（IGF）-I水平
Clin Pediatr Endocrinol. 2004;13(1):71-8. doi: 10.1297/cpe.13.71. Epub 2004 Jul 7.
2
Reference values for serum levels of insulin-like growth factor-I and insulin-like growth factor binding protein-3 in Korean children and adolescents.韩国儿童和青少年血清胰岛素样生长因子-I 和胰岛素样生长因子结合蛋白-3 水平的参考值。
Clin Biochem. 2012 Jan;45(1-2):16-21. doi: 10.1016/j.clinbiochem.2011.10.003. Epub 2011 Oct 12.
3
Normative data for insulin-like growth factors (IGFs), IGF-binding proteins, and growth hormone-binding protein in a healthy Spanish pediatric population: age- and sex-related changes.西班牙健康儿童群体中胰岛素样生长因子（IGF）、IGF结合蛋白及生长激素结合蛋白的标准数据：与年龄和性别的相关变化
J Clin Endocrinol Metab. 1993 Dec;77(6):1522-8. doi: 10.1210/jcem.77.6.7505288.
4
Serum levels of insulin-like growth factor (IGF)-binding protein-3 (IGFBP-3) in healthy infants, children, and adolescents: the relation to IGF-I, IGF-II, IGFBP-1, IGFBP-2, age, sex, body mass index, and pubertal maturation.健康婴儿、儿童及青少年血清胰岛素样生长因子（IGF）结合蛋白-3（IGFBP-3）水平：与IGF-I、IGF-II、IGFBP-1、IGFBP-2、年龄、性别、体重指数及青春期成熟的关系
J Clin Endocrinol Metab. 1995 Aug;80(8):2534-42. doi: 10.1210/jcem.80.8.7543116.
5
Serum levels of type I procollagen C-terminal propeptide, insulin-like growth factor-I (IGF-I), and IGF binding protein-3 in obese children and adolescents: relationship to gender, pubertal development, growth, insulin, and nutritional status.肥胖儿童和青少年血清I型前胶原C端前肽、胰岛素样生长因子-I（IGF-I）及IGF结合蛋白-3水平：与性别、青春期发育、生长、胰岛素及营养状况的关系
Metabolism. 1997 Aug;46(8):862-71. doi: 10.1016/s0026-0495(97)90071-8.
6
Normative data for total and free acid-labile subunit of the human insulin-like growth factor-binding protein complex in pre- and full-term newborns and healthy boys and girls throughout postnatal development.足月前和足月新生儿以及出生后发育过程中的健康男孩和女孩体内人胰岛素样生长因子结合蛋白复合物的总酸不稳定亚基和游离酸不稳定亚基的标准数据。
Horm Res. 2000;53(3):148-53. doi: 10.1159/000023554.
7
Serum IGF-I and IGFBP-3 levels of Turkish children during childhood and adolescence: establishment of reference ranges with emphasis on puberty.土耳其儿童在童年和青春期的血清胰岛素样生长因子-I（IGF-I）和胰岛素样生长因子结合蛋白-3（IGFBP-3）水平：建立参考范围并着重关注青春期。
Horm Res. 2006;65(2):96-105. doi: 10.1159/000091301. Epub 2006 Feb 3.
8
Insulin treatment normalizes reduced free insulin-like growth factor-I concentrations in diabetic children.胰岛素治疗可使糖尿病儿童降低的游离胰岛素样生长因子-I浓度恢复正常。
Clin Endocrinol (Oxf). 1996 Sep;45(3):321-6. doi: 10.1046/j.1365-2265.1996.7760786.x.
9
Acid-labile subunit in growth hormone excess and deficiency in adults: evaluation of its diagnostic value in comparison with insulin-like growth factor (IGF)-I and IGF-binding protein-3.成人生长激素过多和缺乏状态下的酸不稳定亚基：与胰岛素样生长因子（IGF）-I及IGF结合蛋白-3相比对其诊断价值的评估
Endocr J. 2002 Jun;49(3):379-86. doi: 10.1507/endocrj.49.379.
10
The effect of GH therapy on the immunoreactive forms and distribution of IGFBP-3, IGF-I, the acid-labile subunit, and growth rate in GH-deficient children.生长激素（GH）治疗对生长激素缺乏儿童中免疫反应性形式的胰岛素样生长因子结合蛋白-3（IGFBP-3）、胰岛素样生长因子-I（IGF-I）、酸不稳定亚基及生长速率的影响。
Endocrine. 1997 Dec;7(3):351-60. doi: 10.1007/BF02801330.

引用本文的文献

1
Anthropometric and biochemical correlates of PAPP-A2, free IGF-I, and IGFBP-3 in childhood.儿童时期 PAPP-A2、游离 IGF-I 和 IGFBP-3 的人体测量学和生化相关性。
Eur J Endocrinol. 2020 Mar;182(3):363-374. doi: 10.1530/EJE-19-0859.
2
Development of a bioassay system for human growth hormone determination with close correlation to immunoassay.建立与人免疫测定法有密切相关性的人生长激素生物测定系统。
J Clin Lab Anal. 2012 Sep;26(5):328-35. doi: 10.1002/jcla.21527.

本文引用的文献

1
Determination of free insulin-like growth factor-I in human serum: comparison of ultrafiltration and direct immunoradiometric assay.人血清中游离胰岛素样生长因子-I的测定：超滤法与直接免疫放射分析法的比较
Growth Horm IGF Res. 2001 Apr;11(2):117-27. doi: 10.1054/ghir.2001.0197.
2
Acid-labile subunit (ALS) measurements in children.
Endocr J. 2000 Mar;47 Suppl:S111-4. doi: 10.1507/endocrj.47.supplmarch_s111.
3
Insulin: the other anabolic hormone of puberty.
Acta Paediatr Suppl. 1999 Dec;88(433):84-7. doi: 10.1111/j.1651-2227.1999.tb14410.x.
4
Circadian variation in serum free ultrafiltrable insulin-like growth factor I concentrations in healthy children.
Pediatr Res. 1999 May;45(5 Pt 1):733-6. doi: 10.1203/00006450-199905010-00021.
5
Serum free insulin-like growth factor I (IGF-I), total IGF-I, and IGF-binding protein-3 concentrations in normal children and children with growth hormone deficiency.正常儿童和生长激素缺乏症儿童的血清游离胰岛素样生长因子I（IGF-I）、总IGF-I及IGF结合蛋白-3浓度
J Clin Endocrinol Metab. 1999 Jan;84(1):82-9. doi: 10.1210/jcem.84.1.5407.
6
Increase in free insulin-like growth factor-I levels in precocious and normal puberty.
Endocr J. 1998 Jun;45(3):407-12. doi: 10.1507/endocrj.45.407.
7
Free insulin-like growth factor I serum levels in 1430 healthy children and adults, and its diagnostic value in patients suspected of growth hormone deficiency.1430名健康儿童和成人的游离胰岛素样生长因子I血清水平及其在疑似生长激素缺乏患者中的诊断价值。
J Clin Endocrinol Metab. 1997 Aug;82(8):2497-502. doi: 10.1210/jcem.82.8.4137.
8
High ratios of free to total insulin-like growth factor-I in early infancy.
J Clin Endocrinol Metab. 1997 Jan;82(1):156-8. doi: 10.1210/jcem.82.1.3679.
9
Serum concentrations of free and total insulin-like growth factor-I, IGF binding proteins -1 and -3 and IGFBP-3 protease activity in boys with normal or precocious puberty.正常或性早熟男孩血清中游离及总胰岛素样生长因子-I、胰岛素样生长因子结合蛋白-1和-3以及胰岛素样生长因子结合蛋白-3蛋白酶活性
Clin Endocrinol (Oxf). 1996 May;44(5):515-23. doi: 10.1046/j.1365-2265.1996.711531.x.
10
Plasma free insulin-like growth factor I concentrations in growth hormone deficiency in children and adolescents.
Eur J Endocrinol. 1996 Feb;134(2):184-9. doi: 10.1530/eje.0.1340184.