Ogata Tsutomu
Department of Endocrinology and Metabolism, National Research Institute for Child Health and Development, Tokyo, Japan.
Clin Pediatr Endocrinol. 2006;15(2):45-53. doi: 10.1297/cpe.15.45. Epub 2006 Apr 29.
Genes involved in human growth consist of major growth genes and minor growth genes. Major growth genes have fundamental effects on human growth, and their mutations cause growth failure (or overgrowth) which are recognizable as single gene disorders. Minor growth genes exert relative minor additive effects on human growth, and their combination is involved in the development of short (or tall) stature as a multifactorial trait. This review summarizes the current knowledge about the major and the minor growth genes, and refers to the recent molecular approach of identification of the growth genes.
参与人类生长的基因包括主要生长基因和次要生长基因。主要生长基因对人类生长具有根本性影响，其突变会导致生长障碍（或生长过度），这些可被识别为单基因疾病。次要生长基因对人类生长发挥相对较小的累加效应，它们的组合参与了作为多因素性状的身材矮小（或高大）的发生发展。本综述总结了关于主要和次要生长基因的当前知识，并提及了鉴定生长基因的最新分子方法。
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