Moningi Shalini, Armour Elwood P, Terezakis Stephanie A, Efron Jonathan E, Gearhart Susan L, Bivalacqua Trinity J, Kumar Rachit, Le Yi, Kien Ng Sook, Wolfgang Christopher L, Zellars Richard C, Ellsworth Susannah G, Ahuja Nita, Herman Joseph M
Department of Radiation Oncology & Molecular Radiation Sciences, Baltimore, MD, USA.
Department of Surgery, Baltimore, MD, USA.
J Contemp Brachytherapy. 2014 Mar;6(1):99-105. doi: 10.5114/jcb.2014.42027. Epub 2014 Apr 3.
High-dose-rate intraoperative radiation therapy (HDR-IORT) has historically provided effective local control (LC) for patients with unresectable and recurrent tumors. However, IORT is limited to only a few specialized institutions and it can be difficult to initiate an HDR-IORT program. Herein, we provide a brief overview on how to initiate and implement an HDR-IORT program for a selected group of patients with gastrointestinal and pelvic solid tumors using a multidisciplinary approach. Proper administration of HDR-IORT requires institutional support and a joint effort among physics staff, oncologists, surgeons, anesthesiologists, and nurses. In order to determine the true efficacy of IORT for various malignancies, collaboration among institutions with established IORT programs is needed.
高剂量率术中放射治疗（HDR-IORT）在历史上一直为不可切除和复发性肿瘤患者提供有效的局部控制（LC）。然而，IORT仅限于少数几家专业机构，启动HDR-IORT项目可能会很困难。在此，我们简要概述如何使用多学科方法为选定的一组胃肠道和盆腔实体瘤患者启动和实施HDR-IORT项目。正确实施HDR-IORT需要机构支持以及物理工作人员、肿瘤学家、外科医生、麻醉师和护士的共同努力。为了确定IORT对各种恶性肿瘤的真正疗效，需要在已建立IORT项目的机构之间开展合作。
