Calvo Fa, Sole Cv, Herranz R, Lopez-Bote M, Pascau J, Santos A, Muñoz-Calero A, Ferrer C, Garcia-Sabrido Jl
Department of Oncology, Gregorio Marañón General University Hospital, Madrid 28007, Spain ; School of Medicine, Complutense University, Madrid, Spain ; Institute of Research Investigation, Gregorio Marañón General University Hospital, Madrid 28007, Spain.
Ecancermedicalscience. 2013 Aug 15;7:339. doi: 10.3332/ecancer.2013.339. eCollection 2013.
To analyse the programme activity and clinical innovation and/or technology developed over a period of 17 years with regard to the introduction and the use of intraoperative radiotherapy (IORT) as a therapeutic component in a medical-surgical multidisciplinary cancer hospital.
To standardise and record this procedure, the Radiation Oncology service has an institutional programme and protocols that must be completed by the different specialists involved. For 17 years, IORT procedures were recorded on a specific database that includes 23 variables with information recorded on institutional protocols. As part of the development and innovation activity, two technological tools were implemented (RADIANCE and MEDTING) in line with the standardisation of this modality in clinical practice.
During the 17 years studied, 1,004 patients were treated through 1,036 IORT procedures. The state of the disease at the time of IORT was 77% primary and 23% recurrent. The origin and distribution of cancers were 62% gastrointestinal, 18% sarcomas, 5% pancreatic, 2% paediatric, 3% breast, 7% less common locations, and 2% others. The research and development projects have generated a patent on virtual planning (RADIANCE) and proof of concept to explore as a professional social network (MEDTING). During 2012, there were 69 IORT procedures. There was defined treatment volume (target or target region) in all of them, and 43 were conducted by the virtual planning RADIANCE system. Eighteen have been registered on the platform MEDTING as clinical cases.
The IORT programme, developed in a university hospital with an academic tradition, and interdisciplinary surgical oncology, is a feasible care initiative, able to generate the necessary intense clinical activity for tending to the cancer patient. Moreover, it is a competitive source for research, development, and scientific innovation.
分析一家多学科癌症外科医院在17年期间引入和使用术中放疗（IORT）作为治疗手段的项目活动、临床创新和/或技术发展情况。
为规范和记录该程序，放射肿瘤服务部门制定了机构计划和方案，由相关不同专科医生完成。17年来，IORT程序记录在一个特定数据库中，该数据库包含23个变量，记录了机构方案中的信息。作为开发和创新活动的一部分，根据该模式在临床实践中的标准化实施了两种技术工具（RADIANCE和MEDTING）。
在研究的17年中，通过1036例IORT程序治疗了1004例患者。IORT时的疾病状态为77%为原发性，23%为复发性。癌症的起源和分布情况为：62%为胃肠道癌，18%为肉瘤，5%为胰腺癌，2%为儿科癌症，3%为乳腺癌，7%为少见部位癌症，2%为其他癌症。研发项目产生了一项关于虚拟规划（RADIANCE）的专利以及作为专业社交网络探索的概念验证（MEDTING）。2012年，有69例IORT程序。所有程序均确定了治疗体积（靶区或靶区域），其中43例由虚拟规划RADIANCE系统进行。18例已作为临床病例在MEDTING平台上注册。
在具有学术传统的大学医院和跨学科外科肿瘤学中开展的IORT项目是一项可行的护理举措，能够为癌症患者提供必要的密集临床治疗。此外，它是研究、开发和科学创新的一个有竞争力的来源。
