Saleh Zeinab, Arayssi Thurayya
Tufts Medical Center, Boston, MA, USA.
Weill Cornell Medical College-Qatar, Education City, PO Box 24144, Doha, Qatar.
Ther Adv Chronic Dis. 2014 May;5(3):112-34. doi: 10.1177/2040622314523062.
Behçet disease is a chronic inflammatory systemic disorder, characterized by a relapsing and remitting course. It manifests with oral and genital ulcerations, skin lesions, uveitis, and vascular, central nervous system and gastrointestinal involvement. The main histopathological finding is a widespread vasculitis of the arteries and veins of any size. The cause of this disease is presumed to be multifactorial involving infectious triggers, genetic predisposition, and dysregulation of the immune system. As the clinical expression of Behçet disease is heterogeneous, pharmacological therapy is variable and depends largely on the severity of the disease and organ involvement. Treatment of Behçet disease continues to be based largely on anecdotal case reports, case series, and a few randomized clinical trials.
白塞病是一种慢性炎症性全身性疾病，其特点是病情呈复发和缓解过程。临床表现为口腔和生殖器溃疡、皮肤病变、葡萄膜炎以及血管、中枢神经系统和胃肠道受累。主要组织病理学发现是任何大小的动脉和静脉广泛发生血管炎。该疾病的病因被认为是多因素的，涉及感染诱因、遗传易感性和免疫系统失调。由于白塞病的临床表型具有异质性，药物治疗方法各异，很大程度上取决于疾病的严重程度和器官受累情况。白塞病的治疗目前仍主要基于轶事性病例报告、病例系列以及少数随机临床试验。
