Beaussoleil S, Bosgiraud C, Nicolas J A
Laboratoire de Microbiologie, U.F.R. de Pharmacie de Limoges, France.
Rev Infect Dis. 1989 Sep-Oct;11(5):732-40. doi: 10.1093/clinids/11.5.732.
We summarize the pathogenesis of animal lentiviruses (visna-maedi virus, caprine arthritis and encephalitis virus, and equine infectious anemia virus), which have raised considerable interest since the discovery of human lentiviruses. The human lentiviruses possess structural, genetic, and clinical properties similar to those of animal lentiviruses. We describe the different mechanisms of and the principal work on reverse transcriptase inhibitors of animal lentiviruses, such as HPA-23, phosphonoformate, or 2',3'-dideoxynucleosides. Animal viruses of this family may serve as models for infection with human lentiviruses such as human immunodeficiency virus, the etiologic agent of AIDS.
我们总结了动物慢病毒（维斯纳-梅迪病毒、山羊关节炎脑炎病毒和马传染性贫血病毒）的发病机制，自人类慢病毒被发现以来，这些动物慢病毒引起了人们相当大的兴趣。人类慢病毒具有与动物慢病毒相似的结构、遗传和临床特性。我们描述了动物慢病毒逆转录酶抑制剂的不同作用机制及主要研究工作，如HPA-23、膦甲酸或2'，3'-双脱氧核苷。该家族的动物病毒可作为人类慢病毒（如艾滋病病因——人类免疫缺陷病毒）感染的模型。
