Ohnishi Takamasa, Hisaoka Fumiko, Morishima Masaki, Takahashi Akira, Harada Nagakatsu, Mawatari Kazuaki, Arai Hidekazu, Yoshioka Emiko, Toda Satomi, Keisuke Izumi, Nakaya Yutaka
Department of Nutrition Management, Faculty of Health Science, Hyogo University, 2301 Shinzaike, Hiraoka-cho, Kakogawa, Hyogo 675-0195, Japan ; Department of Molecular and Environmental Pathology, Institute of Health Biosciences, The University of Tokushima Graduate School, 3-18-15 Kuramoto-cho, Tokushima, Tokushima 770-8503, Japan.
Faculty of Human Life Science, Shikoku University, 23-1 Ebisuno Furukawa, Oujinn-cho, Tokushima, Tokushima 771-1192, Japan.
J Toxicol Pathol. 2014 Apr;27(1):51-6. doi: 10.1293/tox.2012-0032. Epub 2014 Apr 30.
Studies that investigate the underlying mechanisms of disease and treatment options typically require the use of a suitable animal model. Few suitable animal models exist for left atrial thrombosis. Here, we demonstrated that the Spontaneously-Running-Tokushima-Shikoku (SPORTS) rat - a Wistar strain known for its running ability-is predisposed to the development of thrombi in the left atrium. We investigated the incidence of left atrial thrombosis in male (n = 16) and female (n = 17) SPORTS rats and observed organized atrial thrombosis in 57% and 38% of males and female rats, respectively. In the male rats, systolic blood pressures and heart rates were significantly higher in SPORTS rats than in control Wistar rats. We could not find any evidence of arrhythmias, such as atrial fibrillation, during electrocardiographic examination of SPORTS rats. We believe that the SPORTS rat could serve as a new research model for left atrial thrombosis; further, it may be suitable for research investigating the development of new antithrombotic approaches for the control of atrial thrombosis or familial thrombophilia in humans.
研究疾病潜在机制和治疗方案的研究通常需要使用合适的动物模型。目前针对左心房血栓形成几乎没有合适的动物模型。在此，我们证明了自发奔跑的德岛四国（SPORTS）大鼠——一种以其奔跑能力而闻名的Wistar品系大鼠——易发生左心房血栓形成。我们调查了雄性（n = 16）和雌性（n = 17）SPORTS大鼠左心房血栓形成的发生率，分别在57%的雄性大鼠和38%的雌性大鼠中观察到有组织的心房血栓形成。在雄性大鼠中，SPORTS大鼠的收缩压和心率显著高于对照Wistar大鼠。在对SPORTS大鼠进行心电图检查期间，我们未发现任何心律失常的证据，如心房颤动。我们认为SPORTS大鼠可作为左心房血栓形成的一种新研究模型；此外，它可能适用于研究开发用于控制人类心房血栓形成或家族性血栓形成倾向的新型抗血栓方法。
Zotero 插件
