Kitsantas Panagiota, Gaffney Kathleen F, Wu Huichuan
J Perinat Med. 2015 Jan;43(1):43-52. doi: 10.1515/jpm-2013-0323.
Recent studies indicate that older women are more likely to consume alcohol during pregnancy, but subgroups at highest risk within the context of maternal age have not been identified. This study identifies subgroups at risk for alcohol use during pregnancy among three age categories using classification and regression trees (CART) analysis.
Using the 2002-2009 Pregnancy Risk Assessment Monitoring System (PRAMS) dataset (311,428 records of U.S. women), logistic regression and classification trees were constructed separately for age groups, ≤24, 25-29, and ≥30 years.
Overall, 6.5% of women reported drinking alcohol during the last trimester of pregnancy. Alcohol consumption by age group was: 3.7% for ≤24, 5.7% for 25-29, and 10.1% for ≥30 years of age. Women ≤24 years were at greater risk of consuming alcohol if they also smoked (5.8%). Among nonsmokers, higher levels of education and being Hispanic were associated with a 35% increase in alcohol use. Distinct high-risk subgroups emerged for the 25-29-year-old group. Specifically, 12.8% of non-obese women who reported having experienced abuse during pregnancy also reported drinking alcohol in the last trimester. About 16% of women ≥30 years with at least 16 years of education, White or Hispanic with normal or underweight BMI, drank alcohol during their last trimester.
Given limited health care resources for prevention and treatment, the early identification of high-risk groups for prenatal alcohol use is critical. This study provides evidence that risk factors contributing to alcohol consumption during pregnancy may differ by maternal age.
近期研究表明,年龄较大的女性在孕期饮酒的可能性更高,但尚未确定在母亲年龄范围内风险最高的亚组。本研究使用分类与回归树(CART)分析确定三个年龄类别中孕期饮酒风险亚组。
利用2002 - 2009年妊娠风险评估监测系统(PRAMS)数据集(311,428名美国女性记录),分别为年龄≤24岁、25 - 29岁和≥30岁的年龄组构建逻辑回归模型和分类树。
总体而言,6.5%的女性报告在妊娠晚期饮酒。各年龄组的饮酒情况为:≤24岁组为3.7%,25 - 29岁组为5.7%,≥30岁组为10.1%。≤24岁的女性若同时吸烟,则饮酒风险更高(5.8%)。在不吸烟的女性中,较高的教育水平和西班牙裔身份与饮酒量增加35%相关。25 - 29岁年龄组出现了明显的高风险亚组。具体而言,12.8%报告在孕期遭受虐待的非肥胖女性也报告在妊娠晚期饮酒。约16%教育年限至少16年、BMI正常或体重过轻的≥30岁白人或西班牙裔女性在妊娠晚期饮酒。
鉴于预防和治疗的医疗保健资源有限,尽早识别产前饮酒的高风险群体至关重要。本研究提供的证据表明,孕期饮酒的危险因素可能因母亲年龄而异。