Department of Life and Nanopharmaceutical Science, Kyung Hee University, Seoul 130-701, Republic of Korea; Kyung Hee East-West Pharmaceutical Research Institute, College of Pharmacy, Kyung Hee University, Seoul 130-701, Republic of Korea.
Department of Food and Nutrition, Andong National University, Andong 760-749, Republic of Korea.
Neurosci Lett. 2014 Jun 20;572:58-62. doi: 10.1016/j.neulet.2014.04.034. Epub 2014 May 2.
Brain-derived neurotrophic factor (BDNF) plays a pivotal role in memory consolidation. Previously, we found that the increased mature BDNF (mBDNF) levels in the hippocampal region at a specific time window after the acquisition trial are required for memory consolidation. In the present study, we investigated whether spicatoside A enhances memory consolidation, and whether its effects on memory consolidation are related to hippocampal mBDNF levels. Spicatoside A (2.5, 5, 10 or 20mg/kg) enhanced memory consolidation in a dose-dependent manner, and enhanced memory consolidation was also observed when spicatoside A was administered 1h after the acquisition trial. Concurrently, when spicatoside A was administered immediately or 1h after the acquisition trial, hippocampal mBDNF levels were similar or significantly increased at 9h after the acquisition trial compared to levels at 6h. These results suggest that increased mBDNF levels in the hippocampal region at 9h after the acquisition trial might play a pivotal role in memory consolidation and that spicatoside A might enhance memory consolidation by increasing hippocampal mBDNF levels.
脑源性神经营养因子（BDNF）在记忆巩固中起着关键作用。此前，我们发现获得性试验后特定时间窗口内海马区成熟 BDNF（mBDNF）水平的增加对于记忆巩固是必需的。在本研究中，我们研究了竹节香附甲素是否增强了记忆巩固，以及其对记忆巩固的影响是否与海马 mBDNF 水平有关。竹节香附甲素（2.5、5、10 或 20mg/kg）以剂量依赖性方式增强了记忆巩固，并且在获得性试验后 1 小时给予竹节香附甲素也观察到了增强的记忆巩固。同时，当竹节香附甲素在获得性试验后立即或 1 小时给予时，与获得性试验后 6 小时相比，获得性试验后 9 小时海马区 mBDNF 水平相似或明显增加。这些结果表明，获得性试验后 9 小时海马区 mBDNF 水平的增加可能在记忆巩固中起着关键作用，并且竹节香附甲素可能通过增加海马 mBDNF 水平来增强记忆巩固。
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