School of Psychological Science, Faculty of Science, Technology and Engineering, La Trobe University, Bundoora, Victoria 3086, Australia.
Neurosci Lett. 2012 May 10;516(1):119-23. doi: 10.1016/j.neulet.2012.03.071. Epub 2012 Apr 4.
Recent research has pointed to a role for brain-derived neurotrophic factor (BDNF) in long-term potentiation and memory. The present series of experiments examined the effects of the application of exogenous BDNF on memory consolidation and reconsolidation of a weak training stimulus with the day-old chick, using the passive avoidance learning paradigm. Chicks injected intracranially with 12.5 μg/mL recombinant BDNF immediately after a single-trial training event displayed enhanced retention relative to saline up to 24h post-training. Furthermore, this dose was also shown to enhance retention when administered following initial weak training. Thus, exogenous BDNF was shown to enhance both consolidation and reconsolidation of memory when administered acutely to the day-old chick.
最近的研究指出脑源性神经营养因子（BDNF）在长期增强和记忆中起作用。本系列实验使用被动回避学习范式，检查了外源性 BDNF 对雏鸡弱训练刺激的记忆巩固和再巩固的影响。在单次训练事件后立即向雏鸡脑内注射 12.5μg/ml 重组 BDNF 的雏鸡相对于生理盐水在训练后 24 小时显示出增强的保留。此外，当给予初始弱训练后，该剂量也显示出增强保留。因此，外源性 BDNF 被证明可在急性给予雏鸡时增强记忆的巩固和再巩固。
