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二苯甲氧基哌啶衍生的多巴胺摄取抑制剂的血管作用。

Vascular effects of diphenylmethoxypiperidine-derived dopamine uptake inhibitors.

机构信息

Biomedical Research Infrastructure Center, Winston-Salem State University, Winston Salem, NC, United States; Department of Life Sciences, Winston-Salem State University, Winston Salem, NC, United States; Department of Obstetrics & Gynecology, Wake Forest University School of Medicine, Winston Salem, NC, United States; Hypertension Research & Vascular Center, Wake Forest University School of Medicine, Winston Salem, NC, United States.

Biomedical Research Infrastructure Center, Winston-Salem State University, Winston Salem, NC, United States; Department of Life Sciences, Winston-Salem State University, Winston Salem, NC, United States; Physiology & Pharmacology, Wake Forest University School of Medicine, Winston Salem, NC, United States.

出版信息

Bioorg Med Chem Lett. 2014 Jun 1;24(11):2429-32. doi: 10.1016/j.bmcl.2014.04.040. Epub 2014 Apr 18.

DOI:10.1016/j.bmcl.2014.04.040
PMID:24792462
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4056188/
Abstract

Vascular effects of 4-aryl methoxypiperidinol compounds previously shown to share with cocaine the ability to inhibit the dopamine transporter are described. All the compounds tested inhibit KCl-induced and noradrenaline-dependent contractions in mesenteric arteries ex vivo. Thus, diphenylpyraline and its analogs may have a role as therapeutic options for the treatment of some of the cardiotoxic effects of cocaine intoxications.

摘要

先前已证实具有抑制多巴胺转运体能力的 4-芳基甲氧基哌啶醇类化合物的血管效应被描述。所有测试的化合物均抑制离体肠系膜动脉中 KCl 诱导和去甲肾上腺素依赖性收缩。因此，二苯哌嗪及其类似物可能在治疗可卡因中毒的某些心脏毒性效应方面具有治疗选择的作用。

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