Lü A G, Ke J, Weng S A
Department of Pharmacology, He-nan Medical University, Zhengzhou, China.
Zhongguo Yao Li Xue Bao. 1990 Nov;11(6):518-20.
The effects of amitriptyline (Ami) on isolated rabbit basilar and mesenteric artery rings were studied and compared with verapamil (Ver). Ami inhibited the contraction of the rabbit basilar and mesenteric artery rings evoked by KCl, CaCl2 and norepinephrine, noncompetitively. The pD'2 values for Ami to antagonize effects of KCl, CaCl2, NE on both arteries were 5.79 +/- 0.10 and 4.97 +/- 0.12 (P less than 0.01), 4.50 +/- 0.30 and 4.58 +/- 0.12 (P greater than 0.05), 5.80 +/- 0.13 and 5.56 +/- 0.12 (P less than 0.01), respectively. The characteristics of such effects of Ami were the same as Ver. The results suggest that Ami may block calcium channels and inhibit rabbit basilar artery selectively.
研究了阿米替林（Ami）对离体兔基底动脉和肠系膜动脉环的作用，并与维拉帕米（Ver）进行比较。Ami非竞争性抑制由氯化钾（KCl）、氯化钙（CaCl2）和去甲肾上腺素引起的兔基底动脉和肠系膜动脉环收缩。Ami拮抗KCl、CaCl2、去甲肾上腺素（NE）对两条动脉作用的pD'2值分别为5.79±0.10和4.97±0.12（P<0.01）、4.50±0.30和4.58±0.12（P>0.05）、5.80±0.13和5.56±0.12（P<0.01）。Ami这种作用的特点与Ver相同。结果表明，Ami可能阻断钙通道并选择性抑制兔基底动脉。
