Fekih-Mrissa Najiba, Mrad Meriem, Riahi Anis, Sayeh Aicha, Zaouali Jamel, Gritli Nasreddine, Mrissa Ridha
Hôpital Militaire Principal d'Instruction de Tunis, Service d'Hématologie, Laboratoire de Biologie Moléculaire, 1008 Montfleury, Tunis, Tunisie; Académie Militaire Fondouk Jédid, 8012 Nabeul, Tunisie.
Hôpital Militaire Principal d'Instruction de Tunis, Service d'Hématologie, Laboratoire de Biologie Moléculaire, 1008 Montfleury, Tunis, Tunisie; Université de Tunis El Manar, Faculté des Sciences de Tunis, 2092, El Manar, Tunisie.
Clin Neurol Neurosurg. 2014 Jun;121:19-22. doi: 10.1016/j.clineuro.2014.03.014. Epub 2014 Mar 19.
UNLABELLED: Human leukocyte antigen (HLA) alleles have been implicated in many autoimmune diseases. The aim of this study is to assess whether HLA-DR/DQ alleles confer susceptibility to Guillain-Barré syndrome (GBS) in a Tunisian population. METHODS: The HLA-DR/DQ genotyping was performed using polymerase chain reaction sequence-specific primers (PCR-SSP) in 38 patients with GBS and 100 healthy Tunisian control subjects. RESULTS: GBS in Tunisian patients was found to be associated with the following alleles with these relative patient versus control frequencies (pc denotes Bonferroni corrected probability values): DRB113 (23.68% vs. 9.0%; pc=0.01), followed by DRB114 (22.36% vs.5.5%; pc<10(-3)). Two haplotypes, DRB114/DQB105 and DRB113/DQB103, were found to be associated with susceptibility to GBS. However DRB107/DQB102 and DRB103/DQB102 haplotypes were more frequently observed in controls than in patients (11.5% vs.7.9%; pc=0.007 and 23% vs. 5.26%; pc<10(-3) respectively). These haplotypes seem to confer protection against the disease. CONCLUSION: Our data demonstrated a new GBS predisposition associated with HLA-DRB114 and DRB113. Theses alleles could be predisposing genetic factors for GBS in the Tunisian population.
未标注：人类白细胞抗原（HLA）等位基因与许多自身免疫性疾病有关。本研究的目的是评估HLA - DR/DQ等位基因是否使突尼斯人群易患吉兰 - 巴雷综合征（GBS）。 方法：采用聚合酶链反应序列特异性引物（PCR - SSP）对38例GBS患者和100名健康突尼斯对照者进行HLA - DR/DQ基因分型。 结果：突尼斯患者的GBS与以下等位基因相关，其患者与对照的相对频率如下（pc表示经Bonferroni校正的概率值）：DRB113（23.68%对9.0%；pc = 0.01），其次是DRB114（22.36%对5.5%；pc < 10⁻³）。发现两种单倍型DRB114/DQB105和DRB113/DQB103与GBS易感性相关。然而，DRB107/DQB102和DRB103/DQB102单倍型在对照中比在患者中更常见（分别为11.5%对7.9%；pc = 0.007和23%对5.26%；pc < 10⁻³）。这些单倍型似乎对该疾病有保护作用。 结论：我们的数据表明与HLA - DRB114和DRB113相关的一种新的GBS易感性。这些等位基因可能是突尼斯人群中GBS的易感遗传因素。
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