突尼斯患者中HLA - DR/DQ基因多态性与吉兰 - 巴雷综合征的关联
Association of HLA-DR/DQ polymorphisms with Guillain-Barré syndrome in Tunisian patients.
作者信息
Fekih-Mrissa Najiba, Mrad Meriem, Riahi Anis, Sayeh Aicha, Zaouali Jamel, Gritli Nasreddine, Mrissa Ridha
机构信息
Hôpital Militaire Principal d'Instruction de Tunis, Service d'Hématologie, Laboratoire de Biologie Moléculaire, 1008 Montfleury, Tunis, Tunisie; Académie Militaire Fondouk Jédid, 8012 Nabeul, Tunisie.
Hôpital Militaire Principal d'Instruction de Tunis, Service d'Hématologie, Laboratoire de Biologie Moléculaire, 1008 Montfleury, Tunis, Tunisie; Université de Tunis El Manar, Faculté des Sciences de Tunis, 2092, El Manar, Tunisie.
出版信息
Clin Neurol Neurosurg. 2014 Jun;121:19-22. doi: 10.1016/j.clineuro.2014.03.014. Epub 2014 Mar 19.
UNLABELLED
Human leukocyte antigen (HLA) alleles have been implicated in many autoimmune diseases. The aim of this study is to assess whether HLA-DR/DQ alleles confer susceptibility to Guillain-Barré syndrome (GBS) in a Tunisian population.
METHODS
The HLA-DR/DQ genotyping was performed using polymerase chain reaction sequence-specific primers (PCR-SSP) in 38 patients with GBS and 100 healthy Tunisian control subjects.
RESULTS
GBS in Tunisian patients was found to be associated with the following alleles with these relative patient versus control frequencies (pc denotes Bonferroni corrected probability values): DRB113 (23.68% vs. 9.0%; pc=0.01), followed by DRB114 (22.36% vs.5.5%; pc<10(-3)). Two haplotypes, DRB114/DQB105 and DRB113/DQB103, were found to be associated with susceptibility to GBS. However DRB107/DQB102 and DRB103/DQB102 haplotypes were more frequently observed in controls than in patients (11.5% vs.7.9%; pc=0.007 and 23% vs. 5.26%; pc<10(-3) respectively). These haplotypes seem to confer protection against the disease.
CONCLUSION
Our data demonstrated a new GBS predisposition associated with HLA-DRB114 and DRB113. Theses alleles could be predisposing genetic factors for GBS in the Tunisian population.
未标注
人类白细胞抗原（HLA）等位基因与许多自身免疫性疾病有关。本研究的目的是评估HLA - DR/DQ等位基因是否使突尼斯人群易患吉兰 - 巴雷综合征（GBS）。
方法
采用聚合酶链反应序列特异性引物（PCR - SSP）对38例GBS患者和100名健康突尼斯对照者进行HLA - DR/DQ基因分型。
结果
突尼斯患者的GBS与以下等位基因相关，其患者与对照的相对频率如下（pc表示经Bonferroni校正的概率值）：DRB113（23.68%对9.0%；pc = 0.01），其次是DRB114（22.36%对5.5%；pc < 10⁻³）。发现两种单倍型DRB114/DQB105和DRB113/DQB103与GBS易感性相关。然而，DRB107/DQB102和DRB103/DQB102单倍型在对照中比在患者中更常见（分别为11.5%对7.9%；pc = 0.007和23%对5.26%；pc < 10⁻³）。这些单倍型似乎对该疾病有保护作用。
结论
我们的数据表明与HLA - DRB114和DRB113相关的一种新的GBS易感性。这些等位基因可能是突尼斯人群中GBS的易感遗传因素。
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