突尼斯患者中HLA - DR/DQ多态性与慢性炎性脱髓鞘性多发性神经根神经病（CIDP）的关联。
Association of HLA-DR/DQ polymorphism with chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) in Tunisian patients.
作者信息
Mrad Meriem, Fekih-Mrissa Najiba, Mansour Malek, Seyah Aicha, Riahi Anis, Gritli Nasreddine, Mrissa Ridha
机构信息
Université Tunis el Manar, Faculté des Science de Tunis, El Manar, Tunisia; Hôpital Militaire Principal d'Instruction de Tunis, Service d'Hématologie, Laboratoire de Biologie Moléculaire, 1008 Montfleury, Tunisia.
出版信息
Transfus Apher Sci. 2013 Dec;49(3):623-6. doi: 10.1016/j.transci.2013.07.024. Epub 2013 Aug 3.
BACKGROUND AND OBJECTIVE
Chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) is an immune-mediated disorder of the peripheral nervous system (PNS). The aim of this study was to investigate associations between HLA-DR/DQ alleles and CIDP in Tunisian patients.
PATIENTS AND METHODS
HLA DR/DQ genotyping was performed using polymerase chain reaction sequence-specific primers (PCR-SSP) with 36 CIDP patients and 100 healthy individuals serving as the control group.
RESULTS
CIDP in Tunisian patients was found to be associated with the HLA-DRB113 allele (pc=0.03) (where pc denotes the Bonferroni corrected probability value). Moreover, the two haplotypes, DRB113/DQB106 (22.22% of patients vs. 8.5% of controls, pc=0.017) and DRB107/DQB1*03 (13.88% of patients vs. 3% of controls, pc=0.005), were found to confer a susceptibility to CIDP.
CONCLUSION
To our knowledge, this is the first study performed to analyze the association of HLA-DRB1/DQB1 alleles on CIDP susceptibility in a Tunisian population.
背景与目的
慢性炎症性脱髓鞘性多发性神经根神经病（CIDP）是一种免疫介导的周围神经系统（PNS）疾病。本研究旨在调查突尼斯患者中HLA - DR/DQ等位基因与CIDP之间的关联。
患者与方法
采用聚合酶链反应序列特异性引物（PCR - SSP）对36例CIDP患者和100名健康个体作为对照组进行HLA DR/DQ基因分型。
结果
发现突尼斯患者中的CIDP与HLA - DRB113等位基因相关（pc = 0.03）（其中pc表示经Bonferroni校正的概率值）。此外，还发现两种单倍型，DRB113/DQB106（患者中占22.22%，对照组中占8.5%，pc = 0.017）和DRB107/DQB1*03（患者中占13.88%，对照组中占3%，pc = 0.005），会使患者易患CIDP。
结论
据我们所知，这是第一项分析突尼斯人群中HLA - DRB1/DQB1等位基因与CIDP易感性之间关联的研究。
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