Thomas Nicole M, Brook Itzhak
Uniformed Services University of the Health Sciences, Department of Pediatrics , Bethesda, MD , USA.
Expert Opin Pharmacother. 2014 Jun;15(8):1069-83. doi: 10.1517/14656566.2014.903920. Epub 2014 May 3.
Acute otitis media (AOM) is the most common childhood bacterial infection and also the leading cause of conductive hearing loss in children. Currently, there is an urgent need for developing novel therapeutic agents for treating AOM.
Structured search of current literature. PubMed was searched for published literature in areas of pharmacotherapeutics, preventive therapies and complementary treatments for OM. The intent of this review is to provide a comprehensive evaluation of therapeutics for AOM, including preventive modalities and complementary medicine.
the management of AOM in young children is still evolving and depends on patterns of bacterial colonization and antimicrobial resistance in the community. The introduction of vaccinations against potential respiratory tract pathogens has altered the frequency of recovery of pathogens causing ear infections in children. Even though not all patients require antimicrobial therapy to overcome their infection, these agents improve symptoms faster and lead to fewer treatment failures. Further studies are warranted to evaluate which patients would best benefit from antimicrobial therapy.
急性中耳炎(AOM)是儿童最常见的细菌感染,也是儿童传导性听力损失的主要原因。目前,迫切需要开发治疗AOM的新型治疗药物。
对当前文献进行结构化检索。在PubMed上搜索了关于中耳炎药物治疗、预防治疗和补充治疗领域的已发表文献。本综述的目的是对AOM的治疗方法进行全面评估,包括预防方式和补充医学。
幼儿AOM的管理仍在不断发展,取决于社区中的细菌定植模式和抗菌药物耐药性。针对潜在呼吸道病原体的疫苗接种改变了引起儿童耳部感染的病原体的检出频率。尽管并非所有患者都需要抗菌治疗来克服感染,但这些药物能更快改善症状,且治疗失败的情况更少。有必要进一步研究以评估哪些患者将从抗菌治疗中获益最大。